Layer 4 Burst Irregular Bitufted Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 4
Keywords: burst irregular,Layer 4,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000217
bIR215_L4_BTC_22df25e508_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000217
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.56 mV
Rheobase Current Interval (0.13321, 0.13458] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -70.00 mV) 0.0274 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 6.0126 mV
AP 1 Steady State Amplitude Change 6.8952 mV
AP 1 Amplitude 82.8918 mV
AP 1 Width at Half Height 0.4500 ms
AP 1 Width (Peak To Trough) 2.8300 ms
AP 1 Rate of Change Peak to Trough -36.6946 mV/ms
AP 1 AHP Depth 20.9540 mV
AP2 Amplitude 76.8792 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 2.9200 ms
AP 2 Rate of Change Peak to Trough -33.4967 mV/ms
AP 2 AHP Depth 20.9311 mV
AP 1-2 Amplitude Change Percent -7.2535 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.7150 %
AP 1-2 AHP Depth Percent Change -0.1093 %
Input Resistance 247.2983 MΩ
AP 1 Delay Mean 6.4800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 36.4800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 34.2350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -60.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1174 %/ms
Accommodation at Steady State Mean -86.6347 %
Accommodation Rate Mean at Steady State 114.7334 ms
ISI CV 3.3794
ISI Median 142.3300 ms
ISI Burst Mean Change 28.2333 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.3500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.3600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.2100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2115.5600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 81.2337 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6347.0 µm2
Number of Stems 4.0
Number of Bifurcations 24.0
Number of Branches 51.0
Overall Width 271.262 µm
Overall Height 516.685 µm
Overall Depth 236.94 µm
Average Diameter 0.684544 µm
Total Length 3722.84 µm
Total Surface 7172.93 µm2
Total Volume 2798.68 µm3
Max Euclidean Distance 474.971 µm
Max Path Distance 533.192 µm
Max Branch Order 5.0
Average Contraction 0.953498
Total Fragmentation 1476.0
Partition Asymmetry 0.468452
Average Rall's Ratio 1.06357
Average Bifurcation Angle Local 59.5851 °
Average Bifurcation Angle Remote 79.5995 °
Fractal Dimension 1.00697
Complexity Summary
State Equations 2021
Optimal Time-Step 0.00777 ms
Relative Complexity 506.64 HH
Model Size
Sections 52
Compartments 182
State Equations 2021
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00777 ms
Optimal Time-Step Error 0.15 %
Optimal Time-Step Benchmark Run Time 506.64 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.07 %
Max. Stable Time-Step Benchmark Run Time 984.43 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16610 Hz
CVODE Steps Per AP 390
CVODE Benchmark Run Time 531.16 HH
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