Layer 4 Burst Irregular Bipolar Cell (5)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: burst irregular,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000216
bIR215_L4_BP_d04c4872bd_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000216
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.35 mV
Rheobase Current Interval (0.03481, 0.03503] nA
Threshold Current Interval (0.00000, 0.05676] nA
Bias Current (to -70.00 mV) 0.0088 nA
Testing Temperature 34.0 °C
Stability Interval [0.0, 14.53125] nA
AP 1-2 Amplitude Drop 4.3827 mV
AP 1 Steady State Amplitude Change 4.4230 mV
AP 1 Amplitude 92.8618 mV
AP 1 Width at Half Height 0.3900 ms
AP 1 Width (Peak To Trough) 1.7400 ms
AP 1 Rate of Change Peak to Trough -67.9443 mV/ms
AP 1 AHP Depth 25.3613 mV
AP2 Amplitude 88.4791 mV
AP2 Width at Half Height 0.3700 ms
AP 2 Width (Peak to Trough) 1.6900 ms
AP 2 Rate of Change Peak to Trough -67.2538 mV/ms
AP 2 AHP Depth 25.1799 mV
AP 1-2 Amplitude Change Percent -4.7195 %
AP 1-2 Half Width Change Percent -5.1282 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.0161 %
AP 1-2 AHP Depth Percent Change -0.7151 %
Input Resistance 913.9477 MΩ
AP 1 Delay Mean 3.5500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 44.9000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 94.0100 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0827 %/ms
Accommodation at Steady State Mean -80.7864 %
Accommodation Rate Mean at Steady State 129.3709 ms
ISI CV 3.6152
ISI Median 205.5500 ms
ISI Burst Mean Change 254.7037 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 20.5200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 20.1350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2219.0200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 56.0257 µm
Overall Height 991.841 µm
Overall Depth 32.1 µm
Average Diameter 1.07428 µm
Total Length 1369.21 µm
Total Surface 2788.86 µm2
Total Volume 931.688 µm3
Max Euclidean Distance 1020.65 µm
Max Path Distance 1036.46 µm
Max Branch Order 6.0
Average Contraction 0.990942
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 47.5212 °
Average Bifurcation Angle Remote 44.5534 °
Fractal Dimension 1.00177
Complexity Summary
State Equations 811
Optimal Time-Step 0.00783 ms
Relative Complexity 194.37 HH
Model Size
Sections 16
Compartments 72
State Equations 811
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00783 ms
Optimal Time-Step Error 0.28 %
Optimal Time-Step Benchmark Run Time 194.37 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.26 %
Max. Stable Time-Step Benchmark Run Time 380.51 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17287 Hz
CVODE Steps Per AP 551
CVODE Benchmark Run Time 228.21 HH
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