Layer 2/3 Burst Irregular Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: burst irregular,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst irregular double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000210
bIR215_L23_DBC_b0d0b3615e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000210
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.40 mV
Rheobase Current Interval (0.06409, 0.06500] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -70.00 mV) 0.0143 nA
Testing Temperature 34.0 °C
Stability Interval [-0.625, 15.0] nA
AP 1-2 Amplitude Drop 4.3283 mV
AP 1 Steady State Amplitude Change 5.3732 mV
AP 1 Amplitude 78.0170 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 3.5600 ms
AP 1 Rate of Change Peak to Trough -27.1187 mV/ms
AP 1 AHP Depth 18.5256 mV
AP2 Amplitude 73.6888 mV
AP2 Width at Half Height 0.5500 ms
AP 2 Width (Peak to Trough) 3.9500 ms
AP 2 Rate of Change Peak to Trough -23.5271 mV/ms
AP 2 AHP Depth 19.2432 mV
AP 1-2 Amplitude Change Percent -5.5478 %
AP 1-2 Half Width Change Percent 1.8519 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.2441 %
AP 1-2 AHP Depth Percent Change 3.8734 %
Input Resistance 463.0138 MΩ
AP 1 Delay Mean 8.8400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 39.5600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 34.8400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1099 %/ms
Accommodation at Steady State Mean -87.7836 %
Accommodation Rate Mean at Steady State 122.0880 ms
ISI CV 3.1908
ISI Median 153.5550 ms
ISI Burst Mean Change 26.8229 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.3300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 20.1100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.0700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2075.9300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 105.6562 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1585.85 µm2
Number of Stems 4.0
Number of Bifurcations 23.0
Number of Branches 49.0
Overall Width 217.058 µm
Overall Height 436.996 µm
Overall Depth 80.17 µm
Average Diameter 0.665245 µm
Total Length 2267.38 µm
Total Surface 4374.46 µm2
Total Volume 1165.98 µm3
Max Euclidean Distance 278.209 µm
Max Path Distance 303.307 µm
Max Branch Order 7.0
Average Contraction 0.970188
Total Fragmentation 1031.0
Partition Asymmetry 0.57891
Average Rall's Ratio 1.03286
Average Bifurcation Angle Local 33.6603 °
Average Bifurcation Angle Remote 47.9097 °
Fractal Dimension 1.00476
Complexity Summary
Relative Complexity 339.46 HH
State Equations 1317
Optimal Time-Step 0.00745 ms
Model Size
Sections 50
Compartments 118
State Equations 1317
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15950 Hz
CVODE Steps Per AP 433
CVODE Benchmark Run Time 339.46 HH
Website & Images Copyright NeuroML © 2024 For questions: Contact us Links: Search Test |  ModelDB WS