Layer 2/3 Burst Irregular Double Bouquet Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: burst irregular,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst irregular double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000209
bIR215_L23_DBC_8485afb4d4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000209
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.49 mV
Rheobase Current Interval (0.07484, 0.07553] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -70.00 mV) 0.0159 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 5.0503 mV
AP 1 Steady State Amplitude Change 5.7770 mV
AP 1 Amplitude 87.2748 mV
AP 1 Width at Half Height 0.4300 ms
AP 1 Width (Peak To Trough) 1.9700 ms
AP 1 Rate of Change Peak to Trough -55.8663 mV/ms
AP 1 AHP Depth 22.7819 mV
AP2 Amplitude 82.2245 mV
AP2 Width at Half Height 0.4200 ms
AP 2 Width (Peak to Trough) 1.9500 ms
AP 2 Rate of Change Peak to Trough -53.9483 mV/ms
AP 2 AHP Depth 22.9747 mV
AP 1-2 Amplitude Change Percent -5.7867 %
AP 1-2 Half Width Change Percent -2.3256 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.4333 %
AP 1-2 AHP Depth Percent Change 0.8464 %
Input Resistance 436.1753 MΩ
AP 1 Delay Mean 5.2800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 35.4100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.9950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1224 %/ms
Accommodation at Steady State Mean -86.3608 %
Accommodation Rate Mean at Steady State 119.0895 ms
ISI CV 3.3420
ISI Median 140.6400 ms
ISI Burst Mean Change 25.6555 %
Spike Rate (Strong Stimulation) 15.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.7400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.9500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.2800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2106.7500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 82.0488 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2765.68 µm2
Number of Stems 3.0
Number of Bifurcations 24.0
Number of Branches 50.0
Overall Width 206.485 µm
Overall Height 582.825 µm
Overall Depth 92.87 µm
Average Diameter 0.584713 µm
Total Length 3011.74 µm
Total Surface 4907.18 µm2
Total Volume 1386.51 µm3
Max Euclidean Distance 335.66 µm
Max Path Distance 504.156 µm
Max Branch Order 9.0
Average Contraction 0.963327
Total Fragmentation 1100.0
Partition Asymmetry 0.554418
Average Rall's Ratio 1.12045
Average Bifurcation Angle Local 61.9167 °
Average Bifurcation Angle Remote 62.4689 °
Fractal Dimension 1.00524
Complexity Summary
Relative Complexity 475.55 HH
State Equations 1735
Optimal Time-Step 0.00786 ms
Model Size
Sections 52
Compartments 156
State Equations 1735
Variable Time-Step Complexity
CVODE Steady State Step Frequency 17922 Hz
CVODE Steps Per AP 432
CVODE Benchmark Run Time 475.55 HH
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