Layer 2/3 Burst Irregular Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: burst irregular,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000208
bIR215_L23_DBC_56fd12fad5_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000208
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.01 mV
Rheobase Current Interval (0.07759, 0.07828] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -70.00 mV) 0.0169 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 3.9173 mV
AP 1 Steady State Amplitude Change 4.8449 mV
AP 1 Amplitude 87.0890 mV
AP 1 Width at Half Height 0.4100 ms
AP 1 Width (Peak To Trough) 2.1400 ms
AP 1 Rate of Change Peak to Trough -50.9509 mV/ms
AP 1 AHP Depth 21.9458 mV
AP2 Amplitude 83.1718 mV
AP2 Width at Half Height 0.4100 ms
AP 2 Width (Peak to Trough) 2.1400 ms
AP 2 Rate of Change Peak to Trough -49.0475 mV/ms
AP 2 AHP Depth 21.7899 mV
AP 1-2 Amplitude Change Percent -4.4980 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.7357 %
AP 1-2 AHP Depth Percent Change -0.7105 %
Input Resistance 450.8022 MΩ
AP 1 Delay Mean 6.1800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 36.3900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 33.9650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -40.0000 %
Steady State Accommodation Mean -60.0000 %
Accommodation Rate to Steady State -0.1832 %/ms
Accommodation at Steady State Mean -86.0527 %
Accommodation Rate Mean at Steady State 116.1450 ms
ISI CV 3.3721
ISI Median 138.7000 ms
ISI Burst Mean Change 24.8593 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 1.9900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.4000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.5050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2116.5300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 44.9891 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3531.73 µm2
Number of Stems 6.0
Number of Bifurcations 29.0
Number of Branches 63.0
Overall Width 214.624 µm
Overall Height 326.396 µm
Overall Depth 69.33 µm
Average Diameter 0.645303 µm
Total Length 2718.11 µm
Total Surface 3883.48 µm2
Total Volume 1354.43 µm3
Max Euclidean Distance 312.415 µm
Max Path Distance 322.798 µm
Max Branch Order 6.0
Average Contraction 0.977955
Total Fragmentation 1090.0
Partition Asymmetry 0.462069
Average Rall's Ratio 0.71625
Average Bifurcation Angle Local 56.1174 °
Average Bifurcation Angle Remote 70.1121 °
Fractal Dimension 1.00355
Complexity Summary
State Equations 1559
Optimal Time-Step 0.00795 ms
Relative Complexity 365.57 HH
Model Size
Sections 64
Compartments 140
State Equations 1559
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00795 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 365.57 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.48 %
Max. Stable Time-Step Benchmark Run Time 726.57 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15900 Hz
CVODE Steps Per AP 439
CVODE Benchmark Run Time 387.79 HH
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