Layer 2/3 Burst Irregular Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: burst irregular,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000207
bIR215_L23_DBC_4d1e2d44e8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000207
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -74.50 mV
Rheobase Current Interval (0.11810, 0.11948] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0235 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 5.5676 mV
AP 1 Steady State Amplitude Change 7.8374 mV
AP 1 Amplitude 73.1070 mV
AP 1 Width at Half Height 0.5800 ms
AP 1 Width (Peak To Trough) 4.6500 ms
AP 1 Rate of Change Peak to Trough -18.2752 mV/ms
AP 1 AHP Depth 11.8728 mV
AP2 Amplitude 67.5394 mV
AP2 Width at Half Height 0.5900 ms
AP 2 Width (Peak to Trough) 5.6800 ms
AP 2 Rate of Change Peak to Trough -14.1275 mV/ms
AP 2 AHP Depth 12.7050 mV
AP 1-2 Amplitude Change Percent -7.6157 %
AP 1-2 Half Width Change Percent 1.7241 %
AP 1-2 Rate of Change Peak to Trough Percent Change -22.6957 %
AP 1-2 AHP Depth Percent Change 7.0095 %
Input Resistance 226.2397 MΩ
AP 1 Delay Mean 9.0400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 36.8400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 29.7500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1007 %/ms
Accommodation at Steady State Mean -88.8641 %
Accommodation Rate Mean at Steady State 143.5310 ms
ISI CV 3.0725
ISI Median 125.1700 ms
ISI Burst Mean Change 14.0288 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.0600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 17.2600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 15.6100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2048.7000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 79.1357 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2139.54 µm2
Number of Stems 3.0
Number of Bifurcations 19.0
Number of Branches 40.0
Overall Width 294.018 µm
Overall Height 437.586 µm
Overall Depth 296.4 µm
Average Diameter 0.745121 µm
Total Length 3754.51 µm
Total Surface 9336.89 µm2
Total Volume 2566.72 µm3
Max Euclidean Distance 346.903 µm
Max Path Distance 366.275 µm
Max Branch Order 7.0
Average Contraction 0.97202
Total Fragmentation 1337.0
Partition Asymmetry 0.465664
Average Rall's Ratio 1.10062
Average Bifurcation Angle Local 47.7165 °
Average Bifurcation Angle Remote 42.2286 °
Fractal Dimension 1.00526
Complexity Summary
State Equations 2164
Optimal Time-Step 0.00776 ms
Relative Complexity 528.75 HH
Model Size
Sections 41
Compartments 195
State Equations 2164
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00776 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 528.75 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.38 %
Max. Stable Time-Step Benchmark Run Time 1024.82 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15811 Hz
CVODE Steps Per AP 363
CVODE Benchmark Run Time 524.32 HH
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