Layer 2/3 Burst Irregular Bitufted Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Keywords: burst irregular,Layer 2, Layer 3, Layer 2/3,Rat, somatosensory cortex, bitufted, biophysical, burst irregular bitufted cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000204
bIR215_L23_BTC_e02ed2d076_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000204
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.29 mV
Rheobase Current Interval (0.13138, 0.13298] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -70.00 mV) 0.0281 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 6.6976 mV
AP 1 Steady State Amplitude Change 7.4290 mV
AP 1 Amplitude 79.8609 mV
AP 1 Width at Half Height 0.4700 ms
AP 1 Width (Peak To Trough) 3.7400 ms
AP 1 Rate of Change Peak to Trough -27.3657 mV/ms
AP 1 AHP Depth 22.4868 mV
AP2 Amplitude 73.1633 mV
AP2 Width at Half Height 0.5000 ms
AP 2 Width (Peak to Trough) 3.8700 ms
AP 2 Rate of Change Peak to Trough -24.8469 mV/ms
AP 2 AHP Depth 22.9940 mV
AP 1-2 Amplitude Change Percent -8.3866 %
AP 1-2 Half Width Change Percent 6.3830 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.2043 %
AP 1-2 AHP Depth Percent Change 2.2559 %
Input Resistance 270.8995 MΩ
AP 1 Delay Mean 7.3300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 40.1900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 56.4700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1636 %/ms
Accommodation at Steady State Mean -85.0077 %
Accommodation Rate Mean at Steady State 114.1834 ms
ISI CV 3.4386
ISI Median 168.8750 ms
ISI Burst Mean Change 143.7005 %
Spike Rate (Strong Stimulation) 13.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.9600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 19.9400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 18.3850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2143.2000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 76.7753 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7191.39 µm2
Number of Stems 7.0
Number of Bifurcations 18.0
Number of Branches 42.0
Overall Width 181.302 µm
Overall Height 337.01 µm
Overall Depth 192.19 µm
Average Diameter 1.02019 µm
Total Length 2662.16 µm
Total Surface 6328.91 µm2
Total Volume 3251.65 µm3
Max Euclidean Distance 212.431 µm
Max Path Distance 250.262 µm
Max Branch Order 5.0
Average Contraction 0.971474
Total Fragmentation 660.0
Partition Asymmetry 0.477778
Average Rall's Ratio 1.40875
Average Bifurcation Angle Local 33.2331 °
Average Bifurcation Angle Remote 38.8519 °
Fractal Dimension 1.00467
Complexity Summary
Relative Complexity 313.87 HH
State Equations 1449
Optimal Time-Step 0.00750 ms
Model Size
Sections 44
Compartments 130
State Equations 1449
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15153 Hz
CVODE Steps Per AP 305
CVODE Benchmark Run Time 313.87 HH
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