Layer 2/3 Burst Irregular Bitufted Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Keywords: burst irregular,Layer 2, Layer 3, Layer 2/3,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000202
bIR215_L23_BTC_a8491dac1c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000202
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -76.48 mV
Rheobase Current Interval (0.21790, 0.21973] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -70.00 mV) 0.0458 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 9.3304 mV
AP 1 Steady State Amplitude Change 9.6011 mV
AP 1 Amplitude 84.4069 mV
AP 1 Width at Half Height 0.4100 ms
AP 1 Width (Peak To Trough) 2.3100 ms
AP 1 Rate of Change Peak to Trough -46.4861 mV/ms
AP 1 AHP Depth 22.9761 mV
AP2 Amplitude 75.0765 mV
AP2 Width at Half Height 0.4400 ms
AP 2 Width (Peak to Trough) 2.4100 ms
AP 2 Rate of Change Peak to Trough -40.4077 mV/ms
AP 2 AHP Depth 22.3061 mV
AP 1-2 Amplitude Change Percent -11.0541 %
AP 1-2 Half Width Change Percent 7.3171 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.0758 %
AP 1-2 AHP Depth Percent Change -2.9162 %
Input Resistance 176.2251 MΩ
AP 1 Delay Mean 5.1600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 39.3400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 49.9850 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0926 %/ms
Accommodation at Steady State Mean -83.1889 %
Accommodation Rate Mean at Steady State 106.6680 ms
ISI CV 3.7382
ISI Median 153.2700 ms
ISI Burst Mean Change 92.4810 %
Spike Rate (Strong Stimulation) 15.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.0100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 18.4700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 17.6200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2191.4300 ms
Frequency Filter Type Band-Pass
Frequency Filter Pass Above 34.5174 Hz
Frequency Filter Pass Below 49.5626 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 19399.3 µm2
Number of Stems 4.0
Number of Bifurcations 44.0
Number of Branches 91.0
Overall Width 240.147 µm
Overall Height 632.865 µm
Overall Depth 192.14 µm
Average Diameter 0.962333 µm
Total Length 3669.64 µm
Total Surface 9143.83 µm2
Total Volume 7171.43 µm3
Max Euclidean Distance 502.188 µm
Max Path Distance 522.817 µm
Max Branch Order 9.0
Average Contraction 0.962395
Total Fragmentation 962.0
Partition Asymmetry 0.554317
Average Rall's Ratio 0.872222
Average Bifurcation Angle Local 59.075 °
Average Bifurcation Angle Remote 67.2405 °
Fractal Dimension 1.00399
Complexity Summary
State Equations 2197
Optimal Time-Step 0.00762 ms
Relative Complexity 541.50 HH
Model Size
Sections 92
Compartments 198
State Equations 2197
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00762 ms
Optimal Time-Step Error 0.19 %
Optimal Time-Step Benchmark Run Time 541.50 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.20 %
Max. Stable Time-Step Benchmark Run Time 1031.04 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 16512 Hz
CVODE Steps Per AP 346
CVODE Benchmark Run Time 541.68 HH
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