Layer 2/3 Burst Irregular Bipolar Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Bipolar Cell
Keywords: burst irregular,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar, biophysical, burst irregular bipolar cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000198
bIR215_L23_BP_a4d3f66d76_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH000115
StochKv_deterministic.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000198
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.67 mV
Rheobase Current Interval (0.03983, 0.04028] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -70.00 mV) 0.0111 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 6.4451 mV
AP 1 Steady State Amplitude Change 5.9256 mV
AP 1 Amplitude 86.4232 mV
AP 1 Width at Half Height 0.4400 ms
AP 1 Width (Peak To Trough) 2.7900 ms
AP 1 Rate of Change Peak to Trough -40.3355 mV/ms
AP 1 AHP Depth 26.1129 mV
AP2 Amplitude 79.9782 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 2.8800 ms
AP 2 Rate of Change Peak to Trough -37.0447 mV/ms
AP 2 AHP Depth 26.7106 mV
AP 1-2 Amplitude Change Percent -7.4576 %
AP 1-2 Half Width Change Percent 2.2727 %
AP 1-2 Rate of Change Peak to Trough Percent Change -8.1586 %
AP 1-2 AHP Depth Percent Change 2.2889 %
Input Resistance 963.7934 MΩ
AP 1 Delay Mean 6.8800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 68.0300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 157.7800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1034 %/ms
Accommodation at Steady State Mean -74.3762 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 3.9025
ISI Median 235.6500 ms
ISI Burst Mean Change 316.0425 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.0100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 22.9500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.3600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2229.0300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2271.45 µm2
Number of Stems 3.0
Number of Bifurcations 6.0
Number of Branches 14.0
Overall Width 52.3845 µm
Overall Height 233.422 µm
Overall Depth 16.26 µm
Average Diameter 1.24674 µm
Total Length 636.744 µm
Total Surface 1717.32 µm2
Total Volume 855.428 µm3
Max Euclidean Distance 138.189 µm
Max Path Distance 160.461 µm
Max Branch Order 3.0
Average Contraction 0.9788
Total Fragmentation 201.0
Partition Asymmetry 0.666667
Average Rall's Ratio 2.385
Average Bifurcation Angle Local 44.2648 °
Average Bifurcation Angle Remote 39.8578 °
Fractal Dimension 1.00316
Complexity Summary
Relative Complexity 77.92 HH
State Equations 338
Optimal Time-Step 0.00775 ms
Model Size
Sections 15
Compartments 29
State Equations 338
Variable Time-Step Complexity
CVODE Steady State Step Frequency 15147 Hz
CVODE Steps Per AP 331
CVODE Benchmark Run Time 77.92 HH
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