Layer 6 Burst Accommodating Nest Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000196
bAC217_L6_NBC_ee7b52323f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000196
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.41 mV
Rheobase Current Interval (0.09201, 0.09338] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0243 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 3.0781 mV
AP 1 Steady State Amplitude Change 3.7228 mV
AP 1 Amplitude 78.9337 mV
AP 1 Width at Half Height 0.4500 ms
AP 1 Width (Peak To Trough) 2.8800 ms
AP 1 Rate of Change Peak to Trough -34.9866 mV/ms
AP 1 AHP Depth 21.8275 mV
AP2 Amplitude 75.8557 mV
AP2 Width at Half Height 0.4600 ms
AP 2 Width (Peak to Trough) 2.9400 ms
AP 2 Rate of Change Peak to Trough -33.3896 mV/ms
AP 2 AHP Depth 22.3097 mV
AP 1-2 Amplitude Change Percent -3.8995 %
AP 1-2 Half Width Change Percent 2.2222 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.5646 %
AP 1-2 AHP Depth Percent Change 2.2088 %
Input Resistance 282.5177 MΩ
AP 1 Delay Mean 11.7400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 51.9800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 46.6350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1083 %/ms
Accommodation at Steady State Mean -85.4163 %
Accommodation Rate Mean at Steady State 135.6928 ms
ISI CV 3.1471
ISI Median 181.3050 ms
ISI Burst Mean Change 31.7843 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.8600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 25.3700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.7250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2040.0400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 56.5269 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10206.9 µm2
Number of Stems 5.0
Number of Bifurcations 16.0
Number of Branches 36.0
Overall Width 299.275 µm
Overall Height 500.178 µm
Overall Depth 372.18 µm
Average Diameter 0.996533 µm
Total Length 3439.72 µm
Total Surface 9153.13 µm2
Total Volume 5055.91 µm3
Max Euclidean Distance 366.658 µm
Max Path Distance 409.037 µm
Max Branch Order 6.0
Average Contraction 0.960011
Total Fragmentation 2083.0
Partition Asymmetry 0.433333
Average Rall's Ratio 1.10958
Average Bifurcation Angle Local 12.9439 °
Average Bifurcation Angle Remote 60.2008 °
Fractal Dimension 1.00773
Complexity Summary
State Equations 1771
Optimal Time-Step 0.00779 ms
Relative Complexity 397.37 HH
Model Size
Sections 37
Compartments 175
State Equations 1771
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.14 %
Optimal Time-Step Benchmark Run Time 397.37 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.15 %
Max. Stable Time-Step Benchmark Run Time 773.33 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12574 Hz
CVODE Steps Per AP 608
CVODE Benchmark Run Time 379.51 HH
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