Layer 6 Burst Accommodating Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000194
bAC217_L6_NBC_3fc0dff69e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000194
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.66 mV
Rheobase Current Interval (0.08240, 0.08377] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0233 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 4.1582 mV
AP 1 Steady State Amplitude Change 8.3220 mV
AP 1 Amplitude 73.4648 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 3.8000 ms
AP 1 Rate of Change Peak to Trough -24.6029 mV/ms
AP 1 AHP Depth 20.0260 mV
AP2 Amplitude 69.3066 mV
AP2 Width at Half Height 0.5400 ms
AP 2 Width (Peak to Trough) 4.0900 ms
AP 2 Rate of Change Peak to Trough -21.6802 mV/ms
AP 2 AHP Depth 19.3654 mV
AP 1-2 Amplitude Change Percent -5.6602 %
AP 1-2 Half Width Change Percent 5.8824 %
AP 1-2 Rate of Change Peak to Trough Percent Change -11.8794 %
AP 1-2 AHP Depth Percent Change -3.2990 %
Input Resistance 297.0649 MΩ
AP 1 Delay Mean 12.3300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 51.4900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 45.5900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1697 %/ms
Accommodation at Steady State Mean -87.5582 %
Accommodation Rate Mean at Steady State 128.7319 ms
ISI CV 2.9274
ISI Median 189.9600 ms
ISI Burst Mean Change 32.8396 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.7400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.5100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.1750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2047.9300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 44.5788 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9076.81 µm2
Number of Stems 4.0
Number of Bifurcations 30.0
Number of Branches 63.0
Overall Width 373.792 µm
Overall Height 508.138 µm
Overall Depth 133.43 µm
Average Diameter 0.775848 µm
Total Length 3840.86 µm
Total Surface 8896.03 µm2
Total Volume 4432.06 µm3
Max Euclidean Distance 355.408 µm
Max Path Distance 426.516 µm
Max Branch Order 4.0
Average Contraction 0.952473
Total Fragmentation 2725.0
Partition Asymmetry 0.293889
Average Rall's Ratio 1.38
Average Bifurcation Angle Local 33.5714 °
Average Bifurcation Angle Remote 56.3069 °
Fractal Dimension 1.00851
Complexity Summary
State Equations 2041
Optimal Time-Step 0.00780 ms
Relative Complexity 481.59 HH
Model Size
Sections 66
Compartments 202
State Equations 2041
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00780 ms
Optimal Time-Step Error 0.26 %
Optimal Time-Step Benchmark Run Time 481.59 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.42 %
Max. Stable Time-Step Benchmark Run Time 938.98 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12795 Hz
CVODE Steps Per AP 837
CVODE Benchmark Run Time 522.82 HH
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