Layer 6 Burst Accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000192
bAC217_L6_NBC_1ef33fd873_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000192
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.74 mV
Rheobase Current Interval (0.06866, 0.06981] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0225 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.5373 mV
AP 1 Steady State Amplitude Change 1.5475 mV
AP 1 Amplitude 80.9198 mV
AP 1 Width at Half Height 0.4100 ms
AP 1 Width (Peak To Trough) 2.0300 ms
AP 1 Rate of Change Peak to Trough -51.6814 mV/ms
AP 1 AHP Depth 23.9934 mV
AP2 Amplitude 80.3825 mV
AP2 Width at Half Height 0.4100 ms
AP 2 Width (Peak to Trough) 2.0500 ms
AP 2 Rate of Change Peak to Trough -50.7276 mV/ms
AP 2 AHP Depth 23.6090 mV
AP 1-2 Amplitude Change Percent -0.6640 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.8456 %
AP 1-2 AHP Depth Percent Change -1.6022 %
Input Resistance 327.3067 MΩ
AP 1 Delay Mean 14.2900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 56.7400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 46.7400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -60.0000 %
Steady State Accommodation Mean -40.0000 %
Accommodation Rate to Steady State -0.1017 %/ms
Accommodation at Steady State Mean -84.4152 %
Accommodation Rate Mean at Steady State 173.3739 ms
ISI CV 3.0462
ISI Median 175.7400 ms
ISI Burst Mean Change 20.2120 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.0000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 26.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.9150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2048.4300 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7922.87 µm2
Number of Stems 6.0
Number of Bifurcations 37.0
Number of Branches 79.0
Overall Width 422.166 µm
Overall Height 523.608 µm
Overall Depth 270.85 µm
Average Diameter 0.669167 µm
Total Length 5864.28 µm
Total Surface 9039.2 µm2
Total Volume 3607.7 µm3
Max Euclidean Distance 377.429 µm
Max Path Distance 401.341 µm
Max Branch Order 5.0
Average Contraction 0.976237
Total Fragmentation 1849.0
Partition Asymmetry 0.323895
Average Rall's Ratio 0.55
Average Bifurcation Angle Local 31.5691 °
Average Bifurcation Angle Remote 39.289 °
Fractal Dimension 1.00413
Complexity Summary
State Equations 2981
Optimal Time-Step 0.00772 ms
Relative Complexity 726.59 HH
Model Size
Sections 80
Compartments 296
State Equations 2981
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00772 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 726.59 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.29 %
Max. Stable Time-Step Benchmark Run Time 1402.56 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13024 Hz
CVODE Steps Per AP 741
CVODE Benchmark Run Time 754.08 HH
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