Layer 6 Burst Accommodating Martinotti Cell (2)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000188
bAC217_L6_MC_6c575906a7_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000188
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.83 mV
Rheobase Current Interval (0.06454, 0.06592] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0405 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.5847 mV
AP 1 Steady State Amplitude Change 1.0895 mV
AP 1 Amplitude 75.8022 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 2.4700 ms
AP 1 Rate of Change Peak to Trough -38.7198 mV/ms
AP 1 AHP Depth 19.8357 mV
AP2 Amplitude 75.2175 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.4800 ms
AP 2 Rate of Change Peak to Trough -38.2888 mV/ms
AP 2 AHP Depth 19.7386 mV
AP 1-2 Amplitude Change Percent -0.7713 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.1132 %
AP 1-2 AHP Depth Percent Change -0.4896 %
Input Resistance 252.9823 MΩ
AP 1 Delay Mean 23.1400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 77.9600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 61.4150 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1019 %/ms
Accommodation at Steady State Mean -79.8195 %
Accommodation Rate Mean at Steady State 203.7551 ms
ISI CV 3.1053
ISI Median 200.2400 ms
ISI Burst Mean Change 24.0606 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.9000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 33.6600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.2700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2064.2700 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6152.5 µm2
Number of Stems 5.0
Number of Bifurcations 45.0
Number of Branches 94.0
Overall Width 521.191 µm
Overall Height 581.744 µm
Overall Depth 228.97 µm
Average Diameter 0.714617 µm
Total Length 6147.04 µm
Total Surface 13077.0 µm2
Total Volume 4242.09 µm3
Max Euclidean Distance 392.565 µm
Max Path Distance 439.561 µm
Max Branch Order 9.0
Average Contraction 0.936686
Total Fragmentation 5007.0
Partition Asymmetry 0.512609
Average Rall's Ratio 1.49548
Average Bifurcation Angle Local 37.9498 °
Average Bifurcation Angle Remote 63.8135 °
Fractal Dimension 1.01302
Complexity Summary
State Equations 3271
Optimal Time-Step 0.00775 ms
Relative Complexity 821.13 HH
Model Size
Sections 95
Compartments 325
State Equations 3271
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00775 ms
Optimal Time-Step Error 0.11 %
Optimal Time-Step Benchmark Run Time 821.13 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.10 %
Max. Stable Time-Step Benchmark Run Time 1590.83 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12623 Hz
CVODE Steps Per AP 630
CVODE Benchmark Run Time 792.15 HH
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