Layer 6 Burst Accommodating Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000186
bAC217_L6_LBC_e85c51cdb8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000186
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.76 mV
Rheobase Current Interval (0.08812, 0.08972] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0424 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 1.3285 mV
AP 1 Steady State Amplitude Change 2.3562 mV
AP 1 Amplitude 73.1167 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 3.2400 ms
AP 1 Rate of Change Peak to Trough -29.5788 mV/ms
AP 1 AHP Depth 22.7186 mV
AP2 Amplitude 71.7882 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 3.2800 ms
AP 2 Rate of Change Peak to Trough -28.8316 mV/ms
AP 2 AHP Depth 22.7795 mV
AP 1-2 Amplitude Change Percent -1.8170 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.5260 %
AP 1-2 AHP Depth Percent Change 0.2684 %
Input Resistance 215.7229 MΩ
AP 1 Delay Mean 18.7500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.7600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 64.0950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -75.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1417 %/ms
Accommodation at Steady State Mean -82.4472 %
Accommodation Rate Mean at Steady State 169.4654 ms
ISI CV 3.0398
ISI Median 215.5300 ms
ISI Burst Mean Change 46.4718 %
Spike Rate (Strong Stimulation) 10.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.6000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 30.8600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 26.8150 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2066.3500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 32.5154 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 10981.7 µm2
Number of Stems 5.0
Number of Bifurcations 19.0
Number of Branches 42.0
Overall Width 431.84 µm
Overall Height 969.232 µm
Overall Depth 158.59 µm
Average Diameter 0.912695 µm
Total Length 5070.31 µm
Total Surface 14015.2 µm2
Total Volume 7207.07 µm3
Max Euclidean Distance 764.235 µm
Max Path Distance 809.395 µm
Max Branch Order 5.0
Average Contraction 0.955061
Total Fragmentation 5742.0
Partition Asymmetry 0.443609
Average Rall's Ratio 0.835
Average Bifurcation Angle Local 7.71317 °
Average Bifurcation Angle Remote 44.7621 °
Fractal Dimension 1.00911
Complexity Summary
State Equations 2521
Optimal Time-Step 0.00780 ms
Relative Complexity 604.05 HH
Model Size
Sections 42
Compartments 250
State Equations 2521
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00780 ms
Optimal Time-Step Error 0.13 %
Optimal Time-Step Benchmark Run Time 604.05 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.03 %
Max. Stable Time-Step Benchmark Run Time 1178.09 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12503 Hz
CVODE Steps Per AP 661
CVODE Benchmark Run Time 592.28 HH
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