Layer 6 Burst Accommodating Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000185
bAC217_L6_LBC_e2449b7b3c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000185
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.34 mV
Rheobase Current Interval (0.10986, 0.11169] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0454 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 1.9016 mV
AP 1 Steady State Amplitude Change 2.7570 mV
AP 1 Amplitude 63.3260 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 3.3700 ms
AP 1 Rate of Change Peak to Trough -25.3531 mV/ms
AP 1 AHP Depth 22.1141 mV
AP2 Amplitude 61.4244 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 3.4600 ms
AP 2 Rate of Change Peak to Trough -24.1536 mV/ms
AP 2 AHP Depth 22.1470 mV
AP 1-2 Amplitude Change Percent -3.0028 %
AP 1-2 Half Width Change Percent 3.6364 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.7314 %
AP 1-2 AHP Depth Percent Change 0.1486 %
Input Resistance 203.8372 MΩ
AP 1 Delay Mean 19.9800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 73.6600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 61.5750 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0520 %/ms
Accommodation at Steady State Mean -77.8485 %
Accommodation Rate Mean at Steady State 185.7756 ms
ISI CV 3.4474
ISI Median 188.9000 ms
ISI Burst Mean Change 29.4151 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.8600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 31.4800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.4200 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2058.3000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.2992 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11503.0 µm2
Number of Stems 8.0
Number of Bifurcations 16.0
Number of Branches 39.0
Overall Width 359.399 µm
Overall Height 589.189 µm
Overall Depth 433.97 µm
Average Diameter 1.03003 µm
Total Length 5143.95 µm
Total Surface 15347.4 µm2
Total Volume 8477.59 µm3
Max Euclidean Distance 463.429 µm
Max Path Distance 497.673 µm
Max Branch Order 4.0
Average Contraction 0.942895
Total Fragmentation 3348.0
Partition Asymmetry 0.41875
Average Rall's Ratio 0.724333
Average Bifurcation Angle Local 63.5638 °
Average Bifurcation Angle Remote 72.3023 °
Fractal Dimension 1.0118
Complexity Summary
State Equations 2641
Optimal Time-Step 0.00749 ms
Relative Complexity 668.92 HH
Model Size
Sections 40
Compartments 262
State Equations 2641
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00749 ms
Optimal Time-Step Error 0.42 %
Optimal Time-Step Benchmark Run Time 668.92 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.67 %
Max. Stable Time-Step Benchmark Run Time 1251.61 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 32896 Hz
CVODE Steps Per AP -458
CVODE Benchmark Run Time 931.94 HH
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