Layer 6 Burst Accommodating Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000184
bAC217_L6_LBC_a08d7d7c5e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000184
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.71 mV
Rheobase Current Interval (0.08492, 0.08652] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0333 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 2.2265 mV
AP 1 Steady State Amplitude Change 4.7691 mV
AP 1 Amplitude 64.6316 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 3.3600 ms
AP 1 Rate of Change Peak to Trough -26.0383 mV/ms
AP 1 AHP Depth 22.8573 mV
AP2 Amplitude 62.4051 mV
AP2 Width at Half Height 0.5200 ms
AP 2 Width (Peak to Trough) 3.4800 ms
AP 2 Rate of Change Peak to Trough -24.4472 mV/ms
AP 2 AHP Depth 22.6711 mV
AP 1-2 Amplitude Change Percent -3.4449 %
AP 1-2 Half Width Change Percent 1.9608 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.1108 %
AP 1-2 AHP Depth Percent Change -0.8143 %
Input Resistance 265.4074 MΩ
AP 1 Delay Mean 19.6100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 72.0000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 59.7000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1058 %/ms
Accommodation at Steady State Mean -77.4134 %
Accommodation Rate Mean at Steady State 172.0392 ms
ISI CV 3.4890
ISI Median 178.4400 ms
ISI Burst Mean Change 27.9061 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.2300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 31.3200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.0100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2059.0900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 56.2391 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7752.93 µm2
Number of Stems 8.0
Number of Bifurcations 18.0
Number of Branches 43.0
Overall Width 432.186 µm
Overall Height 651.458 µm
Overall Depth 381.34 µm
Average Diameter 0.906985 µm
Total Length 5056.73 µm
Total Surface 11279.0 µm2
Total Volume 4792.9 µm3
Max Euclidean Distance 449.597 µm
Max Path Distance 498.743 µm
Max Branch Order 4.0
Average Contraction 0.968716
Total Fragmentation 1242.0
Partition Asymmetry 0.357407
Average Rall's Ratio 0.94
Average Bifurcation Angle Local 9.48931 °
Average Bifurcation Angle Remote 41.8434 °
Fractal Dimension 1.00696
Complexity Summary
State Equations 2541
Optimal Time-Step 0.00547 ms
Relative Complexity 872.79 HH
Model Size
Sections 46
Compartments 252
State Equations 2541
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00547 ms
Optimal Time-Step Error 0.23 %
Optimal Time-Step Benchmark Run Time 872.79 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 1.13 %
Max. Stable Time-Step Benchmark Run Time 2384.40 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 33647 Hz
CVODE Steps Per AP -338
CVODE Benchmark Run Time 948.99 HH
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