Layer 6 Burst Accommodating Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, burst accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000183
bAC217_L6_LBC_5d73327936_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000183
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.80 mV
Rheobase Current Interval (0.05081, 0.05219] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0269 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 1.2371 mV
AP 1 Steady State Amplitude Change 2.6329 mV
AP 1 Amplitude 68.1314 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 8.7200 ms
AP 1 Rate of Change Peak to Trough -9.6807 mV/ms
AP 1 AHP Depth 16.2841 mV
AP2 Amplitude 66.8943 mV
AP2 Width at Half Height 0.6200 ms
AP 2 Width (Peak to Trough) 9.1600 ms
AP 2 Rate of Change Peak to Trough -9.1025 mV/ms
AP 2 AHP Depth 16.4843 mV
AP 1-2 Amplitude Change Percent -1.8157 %
AP 1-2 Half Width Change Percent 3.3333 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.9728 %
AP 1-2 AHP Depth Percent Change 1.2295 %
Input Resistance 338.2615 MΩ
AP 1 Delay Mean 24.0500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 81.1000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 71.3800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0807 %/ms
Accommodation at Steady State Mean -82.9549 %
Accommodation Rate Mean at Steady State 175.1736 ms
ISI CV 2.8724
ISI Median 238.1200 ms
ISI Burst Mean Change 50.2366 %
Spike Rate (Strong Stimulation) 9.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.6300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.0500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 30.2250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2066.9200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.8972 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5638.92 µm2
Number of Stems 7.0
Number of Bifurcations 19.0
Number of Branches 44.0
Overall Width 397.911 µm
Overall Height 486.605 µm
Overall Depth 239.0 µm
Average Diameter 0.952032 µm
Total Length 3814.8 µm
Total Surface 9829.16 µm2
Total Volume 3540.96 µm3
Max Euclidean Distance 317.045 µm
Max Path Distance 337.87 µm
Max Branch Order 5.0
Average Contraction 0.96837
Total Fragmentation 965.0
Partition Asymmetry 0.549123
Average Rall's Ratio 2.33375
Average Bifurcation Angle Local 15.7801 °
Average Bifurcation Angle Remote 38.0385 °
Fractal Dimension 1.00666
Complexity Summary
Relative Complexity 460.28 HH
State Equations 1961
Optimal Time-Step 0.00776 ms
Model Size
Sections 44
Compartments 194
State Equations 1961
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12866 Hz
CVODE Steps Per AP 683
CVODE Benchmark Run Time 460.28 HH
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