Layer 6 Burst Accommodating Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst accommodating double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000178
bAC217_L6_DBC_3c23ead0b4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000178
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.90 mV
Rheobase Current Interval (0.08469, 0.08698] nA
Threshold Current Interval (0.52734, 0.58594] nA
Bias Current (to -80.00 mV) -0.0556 nA
Testing Temperature 34.0 °C
Stability Interval [-4.0625, 15.0] nA
AP 1-2 Amplitude Drop 0.8416 mV
AP 1 Steady State Amplitude Change 1.4647 mV
AP 1 Amplitude 66.2545 mV
AP 1 Width at Half Height 0.6000 ms
AP 1 Width (Peak To Trough) 5.2200 ms
AP 1 Rate of Change Peak to Trough -16.4234 mV/ms
AP 1 AHP Depth 19.4758 mV
AP2 Amplitude 65.4128 mV
AP2 Width at Half Height 0.6000 ms
AP 2 Width (Peak to Trough) 5.4500 ms
AP 2 Rate of Change Peak to Trough -15.5739 mV/ms
AP 2 AHP Depth 19.4649 mV
AP 1-2 Amplitude Change Percent -1.2703 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.1727 %
AP 1-2 AHP Depth Percent Change -0.0561 %
Input Resistance 183.2978 MΩ
AP 1 Delay Mean 27.6600 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 91.2000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 81.7050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0762 %/ms
Accommodation at Steady State Mean -79.9039 %
Accommodation Rate Mean at Steady State 190.9619 ms
ISI CV 3.0461
ISI Median 244.3600 ms
ISI Burst Mean Change 57.1766 %
Spike Rate (Strong Stimulation) 9.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.0400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 38.6900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.6650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2078.8500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 45.2236 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 9840.66 µm2
Number of Stems 7.0
Number of Bifurcations 36.0
Number of Branches 78.0
Overall Width 315.608 µm
Overall Height 687.636 µm
Overall Depth 109.97 µm
Average Diameter 1.21321 µm
Total Length 4960.76 µm
Total Surface 17752.3 µm2
Total Volume 7739.23 µm3
Max Euclidean Distance 606.985 µm
Max Path Distance 620.83 µm
Max Branch Order 7.0
Average Contraction 0.967489
Total Fragmentation 1862.0
Partition Asymmetry 0.477888
Average Rall's Ratio 1.82983
Average Bifurcation Angle Local 20.4771 °
Average Bifurcation Angle Remote 42.4546 °
Fractal Dimension 1.00546
Complexity Summary
Relative Complexity 649.67 HH
State Equations 2491
Optimal Time-Step 0.00727 ms
Model Size
Sections 81
Compartments 247
State Equations 2491
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12335 Hz
CVODE Steps Per AP 678
CVODE Benchmark Run Time 649.67 HH
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