Layer 6 Burst Accommodating Double Bouquet Cell (1)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000177
bAC217_L6_DBC_2005a958c4_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000177
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.63 mV
Rheobase Current Interval (0.05402, 0.05493] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0275 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 2.4203 mV
AP 1 Steady State Amplitude Change 4.0859 mV
AP 1 Amplitude 71.8578 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 3.3300 ms
AP 1 Rate of Change Peak to Trough -27.2199 mV/ms
AP 1 AHP Depth 18.7846 mV
AP2 Amplitude 69.4374 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 3.4500 ms
AP 2 Rate of Change Peak to Trough -25.5817 mV/ms
AP 2 AHP Depth 18.8193 mV
AP 1-2 Amplitude Change Percent -3.3682 %
AP 1-2 Half Width Change Percent 3.6364 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.0186 %
AP 1-2 AHP Depth Percent Change 0.1847 %
Input Resistance 338.5106 MΩ
AP 1 Delay Mean 16.0700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 62.4000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.8950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0987 %/ms
Accommodation at Steady State Mean -84.3842 %
Accommodation Rate Mean at Steady State 171.7957 ms
ISI CV 3.0041
ISI Median 205.1800 ms
ISI Burst Mean Change 32.6570 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.0800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.6200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.9800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2036.6100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 44.8818 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5585.64 µm2
Number of Stems 3.0
Number of Bifurcations 22.0
Number of Branches 46.0
Overall Width 444.638 µm
Overall Height 632.648 µm
Overall Depth 425.06 µm
Average Diameter 0.65959 µm
Total Length 4868.39 µm
Total Surface 9485.65 µm2
Total Volume 3484.59 µm3
Max Euclidean Distance 379.866 µm
Max Path Distance 545.857 µm
Max Branch Order 7.0
Average Contraction 0.940926
Total Fragmentation 2409.0
Partition Asymmetry 0.445776
Average Rall's Ratio 1.26533
Average Bifurcation Angle Local 29.8711 °
Average Bifurcation Angle Remote 69.4357 °
Fractal Dimension 1.01125
Complexity Summary
State Equations 2471
Optimal Time-Step 0.00788 ms
Relative Complexity 577.27 HH
Model Size
Sections 47
Compartments 245
State Equations 2471
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00788 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 577.27 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.44 %
Max. Stable Time-Step Benchmark Run Time 1137.39 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12949 Hz
CVODE Steps Per AP 739
CVODE Benchmark Run Time 608.57 HH
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