Layer 6 Burst Accommodating Bipolar Cell (3)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 6
Keywords: burst accommodating,Layer 6,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000169
bAC217_L6_BP_b41e8e0c23_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000169
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.54 mV
Rheobase Current Interval (0.02266, 0.02335] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0193 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.3965 mV
AP 1 Steady State Amplitude Change 0.7093 mV
AP 1 Amplitude 77.2523 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 2.5700 ms
AP 1 Rate of Change Peak to Trough -36.4182 mV/ms
AP 1 AHP Depth 16.3425 mV
AP2 Amplitude 76.8558 mV
AP2 Width at Half Height 0.4800 ms
AP 2 Width (Peak to Trough) 2.5900 ms
AP 2 Rate of Change Peak to Trough -36.0063 mV/ms
AP 2 AHP Depth 16.4005 mV
AP 1-2 Amplitude Change Percent -0.5133 %
AP 1-2 Half Width Change Percent -2.0408 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.1312 %
AP 1-2 AHP Depth Percent Change 0.3545 %
Input Resistance 558.7702 MΩ
AP 1 Delay Mean 34.0100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 102.8800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 77.2950 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -75.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0893 %/ms
Accommodation at Steady State Mean -75.3280 %
Accommodation Rate Mean at Steady State 248.2459 ms
ISI CV 3.1815
ISI Median 219.5250 ms
ISI Burst Mean Change 24.4664 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.8900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 42.7300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 33.4550 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2076.3600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 75.6885 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 323.132 µm
Overall Height 518.817 µm
Overall Depth 246.93 µm
Average Diameter 0.633331 µm
Total Length 3853.97 µm
Total Surface 6725.64 µm2
Total Volume 1387.95 µm3
Max Euclidean Distance 330.117 µm
Max Path Distance 394.499 µm
Max Branch Order 6.0
Average Contraction 0.971958
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 33.8405 °
Average Bifurcation Angle Remote 50.5635 °
Fractal Dimension 1.00532
Complexity Summary
State Equations 1991
Optimal Time-Step 0.00773 ms
Relative Complexity 465.27 HH
Model Size
Sections 65
Compartments 197
State Equations 1991
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00773 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 465.27 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.82 %
Max. Stable Time-Step Benchmark Run Time 898.73 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13726 Hz
CVODE Steps Per AP 640
CVODE Benchmark Run Time 475.76 HH
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