Layer 5 Burst Accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: burst accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000162
bAC217_L5_NBC_2db880c523_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000162
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.72 mV
Rheobase Current Interval (0.03845, 0.03937] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0335 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 0.3541 mV
AP 1 Steady State Amplitude Change 0.6513 mV
AP 1 Amplitude 77.9312 mV
AP 1 Width at Half Height 0.4300 ms
AP 1 Width (Peak To Trough) 2.5800 ms
AP 1 Rate of Change Peak to Trough -40.4192 mV/ms
AP 1 AHP Depth 26.3504 mV
AP2 Amplitude 77.5771 mV
AP2 Width at Half Height 0.4400 ms
AP 2 Width (Peak to Trough) 2.5800 ms
AP 2 Rate of Change Peak to Trough -40.2829 mV/ms
AP 2 AHP Depth 26.3528 mV
AP 1-2 Amplitude Change Percent -0.4544 %
AP 1-2 Half Width Change Percent 2.3256 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.3372 %
AP 1-2 AHP Depth Percent Change 0.0093 %
Input Resistance 308.9449 MΩ
AP 1 Delay Mean 34.8100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 114.4800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 108.7450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0651 %/ms
Accommodation at Steady State Mean -74.5889 %
Accommodation Rate Mean at Steady State 237.7161 ms
ISI CV 3.2065
ISI Median 272.1550 ms
ISI Burst Mean Change 72.9886 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.6100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 42.0300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 35.7600 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2123.2900 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5354.07 µm2
Number of Stems 5.0
Number of Bifurcations 34.0
Number of Branches 72.0
Overall Width 382.389 µm
Overall Height 518.62 µm
Overall Depth 185.23 µm
Average Diameter 0.698947 µm
Total Length 5939.77 µm
Total Surface 11834.9 µm2
Total Volume 3758.3 µm3
Max Euclidean Distance 617.541 µm
Max Path Distance 682.074 µm
Max Branch Order 11.0
Average Contraction 0.957906
Total Fragmentation 2033.0
Partition Asymmetry 0.53421
Average Rall's Ratio 1.3125
Average Bifurcation Angle Local 47.1655 °
Average Bifurcation Angle Remote 66.8059 °
Fractal Dimension 1.00725
Complexity Summary
State Equations 3031
Optimal Time-Step 0.00811 ms
Relative Complexity 660.56 HH
Model Size
Sections 73
Compartments 301
State Equations 3031
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00811 ms
Optimal Time-Step Error 0.17 %
Optimal Time-Step Benchmark Run Time 660.56 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.97 %
Max. Stable Time-Step Benchmark Run Time 1339.32 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14162 Hz
CVODE Steps Per AP 514
CVODE Benchmark Run Time 680.29 HH
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