Layer 5 Burst Accommodating Large Basket Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: burst accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, burst accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000156
bAC217_L5_LBC_c2cff91741_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000156
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.51 mV
Rheobase Current Interval (0.15656, 0.15862] nA
Threshold Current Interval (0.46875, 0.52734] nA
Bias Current (to -80.00 mV) -0.0594 nA
Testing Temperature 34.0 °C
Stability Interval [-3.125, 15.0] nA
AP 1-2 Amplitude Drop 3.3955 mV
AP 1 Steady State Amplitude Change 6.8773 mV
AP 1 Amplitude 65.5395 mV
AP 1 Width at Half Height 0.4300 ms
AP 1 Width (Peak To Trough) 2.0900 ms
AP 1 Rate of Change Peak to Trough -44.0554 mV/ms
AP 1 AHP Depth 26.5363 mV
AP2 Amplitude 62.1439 mV
AP2 Width at Half Height 0.4400 ms
AP 2 Width (Peak to Trough) 2.1500 ms
AP 2 Rate of Change Peak to Trough -41.1782 mV/ms
AP 2 AHP Depth 26.3892 mV
AP 1-2 Amplitude Change Percent -5.1809 %
AP 1-2 Half Width Change Percent 2.3256 %
AP 1-2 Rate of Change Peak to Trough Percent Change -6.5309 %
AP 1-2 AHP Depth Percent Change -0.5544 %
Input Resistance 153.0442 MΩ
AP 1 Delay Mean 17.6900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 77.0500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 65.8450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0883 %/ms
Accommodation at Steady State Mean -68.1756 %
Accommodation Rate Mean at Steady State 207.9943 ms
ISI CV 4.0748
ISI Median 156.6900 ms
ISI Burst Mean Change 21.8497 %
Spike Rate (Strong Stimulation) 14.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.4200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.6500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.4850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2118.7000 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.1401 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 16527.3 µm2
Number of Stems 3.0
Number of Bifurcations 55.0
Number of Branches 112.0
Overall Width 558.343 µm
Overall Height 863.591 µm
Overall Depth 185.11 µm
Average Diameter 0.927095 µm
Total Length 8136.74 µm
Total Surface 19652.5 µm2
Total Volume 11963.8 µm3
Max Euclidean Distance 517.161 µm
Max Path Distance 590.804 µm
Max Branch Order 9.0
Average Contraction 0.970497
Total Fragmentation 2965.0
Partition Asymmetry 0.49694
Average Rall's Ratio 0.608056
Average Bifurcation Angle Local 43.3105 °
Average Bifurcation Angle Remote 51.2102 °
Fractal Dimension 1.00492
Complexity Summary
Relative Complexity 1658.88 HH
State Equations 4151
Optimal Time-Step 0.00750 ms
Model Size
Sections 113
Compartments 413
State Equations 4151
Variable Time-Step Complexity
CVODE Steady State Step Frequency 32407 Hz
CVODE Steps Per AP 10
CVODE Benchmark Run Time 1658.88 HH
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