Layer 5 Burst Accommodating Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 5
Keywords: burst accommodating,Layer 5,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000152
bAC217_L5_LBC_01750e1e18_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000152
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.79 mV
Rheobase Current Interval (0.04463, 0.04532] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0162 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 1.6413 mV
AP 1 Steady State Amplitude Change 2.5342 mV
AP 1 Amplitude 80.3210 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 3.0000 ms
AP 1 Rate of Change Peak to Trough -34.2776 mV/ms
AP 1 AHP Depth 22.5118 mV
AP2 Amplitude 78.6797 mV
AP2 Width at Half Height 0.4600 ms
AP 2 Width (Peak to Trough) 3.0600 ms
AP 2 Rate of Change Peak to Trough -33.1818 mV/ms
AP 2 AHP Depth 22.8568 mV
AP 1-2 Amplitude Change Percent -2.0435 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -3.1967 %
AP 1-2 AHP Depth Percent Change 1.5326 %
Input Resistance 503.6134 MΩ
AP 1 Delay Mean 12.3000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 54.3600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 54.0250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1491 %/ms
Accommodation at Steady State Mean -87.2849 %
Accommodation Rate Mean at Steady State 146.4810 ms
ISI CV 2.8384
ISI Median 211.4550 ms
ISI Burst Mean Change 56.8949 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.3000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 27.1500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.1950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2042.3600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 46.0544 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4247.99 µm2
Number of Stems 5.0
Number of Bifurcations 25.0
Number of Branches 54.0
Overall Width 337.503 µm
Overall Height 523.62 µm
Overall Depth 179.66 µm
Average Diameter 0.692476 µm
Total Length 3193.38 µm
Total Surface 6547.59 µm2
Total Volume 2405.74 µm3
Max Euclidean Distance 375.534 µm
Max Path Distance 671.294 µm
Max Branch Order 9.0
Average Contraction 0.956276
Total Fragmentation 2430.0
Partition Asymmetry 0.624322
Average Rall's Ratio 0.914783
Average Bifurcation Angle Local 23.1232 °
Average Bifurcation Angle Remote 60.4036 °
Fractal Dimension 1.00742
Complexity Summary
State Equations 1671
Optimal Time-Step 0.00772 ms
Relative Complexity 398.99 HH
Model Size
Sections 55
Compartments 165
State Equations 1671
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00772 ms
Optimal Time-Step Error 0.13 %
Optimal Time-Step Benchmark Run Time 398.99 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.53 %
Max. Stable Time-Step Benchmark Run Time 769.89 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13173 Hz
CVODE Steps Per AP 710
CVODE Benchmark Run Time 410.64 HH
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