Layer 5 Burst Accommodating Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: burst accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000150
bAC217_L5_DBC_e2f2301440_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000150
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -68.54 mV
Rheobase Current Interval (0.04692, 0.04807] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0459 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.7595 mV
AP 1 Steady State Amplitude Change 1.8674 mV
AP 1 Amplitude 69.1810 mV
AP 1 Width at Half Height 0.5600 ms
AP 1 Width (Peak To Trough) 3.3300 ms
AP 1 Rate of Change Peak to Trough -24.6763 mV/ms
AP 1 AHP Depth 12.9911 mV
AP2 Amplitude 68.4215 mV
AP2 Width at Half Height 0.5700 ms
AP 2 Width (Peak to Trough) 3.4600 ms
AP 2 Rate of Change Peak to Trough -23.4793 mV/ms
AP 2 AHP Depth 12.8168 mV
AP 1-2 Amplitude Change Percent -1.0979 %
AP 1-2 Half Width Change Percent 1.7857 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.8509 %
AP 1-2 AHP Depth Percent Change -1.3413 %
Input Resistance 260.8910 MΩ
AP 1 Delay Mean 27.5400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 86.9000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 66.0000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1006 %/ms
Accommodation at Steady State Mean -79.1588 %
Accommodation Rate Mean at Steady State 234.4511 ms
ISI CV 3.0633
ISI Median 210.3000 ms
ISI Burst Mean Change 22.3720 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.7800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.0100 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.7450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2055.4300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 44.4943 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4654.39 µm2
Number of Stems 4.0
Number of Bifurcations 52.0
Number of Branches 107.0
Overall Width 345.98 µm
Overall Height 664.457 µm
Overall Depth 199.52 µm
Average Diameter 0.732229 µm
Total Length 6749.33 µm
Total Surface 14453.6 µm2
Total Volume 4278.46 µm3
Max Euclidean Distance 471.433 µm
Max Path Distance 755.404 µm
Max Branch Order 11.0
Average Contraction 0.950381
Total Fragmentation 5939.0
Partition Asymmetry 0.490463
Average Rall's Ratio 0.97881
Average Bifurcation Angle Local 28.4407 °
Average Bifurcation Angle Remote 55.5125 °
Fractal Dimension 1.00948
Complexity Summary
State Equations 3381
Optimal Time-Step 0.00779 ms
Relative Complexity 917.94 HH
Model Size
Sections 108
Compartments 336
State Equations 3381
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 917.94 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.64 %
Max. Stable Time-Step Benchmark Run Time 1786.05 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12983 Hz
CVODE Steps Per AP 710
CVODE Benchmark Run Time 943.61 HH
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