Layer 5 Burst Accommodating Double Bouquet Cell (2)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 5
Keywords: burst accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet, biophysical, burst accommodating double bouquet cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000148
bAC217_L5_DBC_7f0bb8efe9_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000148
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.73 mV
Rheobase Current Interval (0.05608, 0.05722] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0325 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 1.5142 mV
AP 1 Steady State Amplitude Change 3.2975 mV
AP 1 Amplitude 72.2453 mV
AP 1 Width at Half Height 0.5000 ms
AP 1 Width (Peak To Trough) 3.8200 ms
AP 1 Rate of Change Peak to Trough -23.6795 mV/ms
AP 1 AHP Depth 18.2103 mV
AP2 Amplitude 70.7311 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 3.9400 ms
AP 2 Rate of Change Peak to Trough -22.5043 mV/ms
AP 2 AHP Depth 17.9359 mV
AP 1-2 Amplitude Change Percent -2.0959 %
AP 1-2 Half Width Change Percent 2.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.9628 %
AP 1-2 AHP Depth Percent Change -1.5071 %
Input Resistance 287.5318 MΩ
AP 1 Delay Mean 25.8000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 97.7600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 137.1400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean 0.0000 %
Steady State Accommodation Mean 0.0000 %
Accommodation Rate to Steady State 0.0000 %/ms
Accommodation at Steady State Mean -38.3545 %
Accommodation Rate Mean at Steady State 2.2585 ms
ISI CV 3.2324
ISI Median 122.7900 ms
ISI Burst Mean Change 181.1562 %
Spike Rate (Strong Stimulation) 10.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.9600 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 34.8900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.4250 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2231.9300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 37.3900 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8381.24 µm2
Number of Stems 5.0
Number of Bifurcations 37.0
Number of Branches 78.0
Overall Width 226.09 µm
Overall Height 1115.16 µm
Overall Depth 163.41 µm
Average Diameter 0.900924 µm
Total Length 4395.23 µm
Total Surface 11736.2 µm2
Total Volume 6009.82 µm3
Max Euclidean Distance 933.998 µm
Max Path Distance 977.957 µm
Max Branch Order 16.0
Average Contraction 0.962433
Total Fragmentation 4757.0
Partition Asymmetry 0.636207
Average Rall's Ratio 0.690357
Average Bifurcation Angle Local 34.9104 °
Average Bifurcation Angle Remote 55.4708 °
Fractal Dimension 1.00825
Complexity Summary
Relative Complexity 633.26 HH
State Equations 2271
Optimal Time-Step 0.00787 ms
Model Size
Sections 79
Compartments 225
State Equations 2271
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14762 Hz
CVODE Steps Per AP 638
CVODE Benchmark Run Time 633.26 HH
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