Layer 5 Burst Accommodating Bitufted Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 5
Keywords: burst accommodating,Layer 5,Rat, somatosensory cortex, bitufted
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000145
bAC217_L5_BTC_8807af3a2b_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: Script fails but not clear why. Manualy instantiated cell works ok. Need to debug.
Model Id: NMLCL000145
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.82 mV
Rheobase Current Interval (0.09453, 0.09613] nA
Threshold Current Interval (0.35156, 0.41016] nA
Bias Current (to -80.00 mV) -0.0528 nA
Testing Temperature 34.0 °C
Stability Interval [-2.8125, 15.0] nA
AP 1-2 Amplitude Drop 0.8903 mV
AP 1 Steady State Amplitude Change 1.9611 mV
AP 1 Amplitude 71.6772 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 3.6800 ms
AP 1 Rate of Change Peak to Trough -24.5738 mV/ms
AP 1 AHP Depth 18.7543 mV
AP2 Amplitude 70.7869 mV
AP2 Width at Half Height 0.5200 ms
AP 2 Width (Peak to Trough) 3.8200 ms
AP 2 Rate of Change Peak to Trough -23.3153 mV/ms
AP 2 AHP Depth 18.2775 mV
AP 1-2 Amplitude Change Percent -1.2420 %
AP 1-2 Half Width Change Percent 1.9608 %
AP 1-2 Rate of Change Peak to Trough Percent Change -5.1212 %
AP 1-2 AHP Depth Percent Change -2.5424 %
Input Resistance 191.5641 MΩ
AP 1 Delay Mean 16.5100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 62.9800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 52.2200 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0552 %/ms
Accommodation at Steady State Mean -82.9807 %
Accommodation Rate Mean at Steady State 181.5543 ms
ISI CV 3.1023
ISI Median 191.4350 ms
ISI Burst Mean Change 24.7471 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.0400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.4300 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 24.6750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2052.0900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 46.4357 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11565.8 µm2
Number of Stems 4.0
Number of Bifurcations 66.0
Number of Branches 135.0
Overall Width 639.046 µm
Overall Height 925.189 µm
Overall Depth 219.17 µm
Average Diameter 1.07777 µm
Total Length 4523.41 µm
Total Surface 15453.0 µm2
Total Volume 8338.35 µm3
Max Euclidean Distance 848.246 µm
Max Path Distance 894.335 µm
Max Branch Order 15.0
Average Contraction 0.930074
Total Fragmentation 4168.0
Partition Asymmetry 0.675002
Average Rall's Ratio 1.32878
Average Bifurcation Angle Local 44.9108 °
Average Bifurcation Angle Remote 74.3303 °
Fractal Dimension 1.01863
Complexity Summary
State Equations 2761
Optimal Time-Step 0.00779 ms
Relative Complexity 653.05 HH
Model Size
Sections 134
Compartments 274
State Equations 2761
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.18 %
Optimal Time-Step Benchmark Run Time 653.05 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.39 %
Max. Stable Time-Step Benchmark Run Time 1271.38 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12903 Hz
CVODE Steps Per AP 561
CVODE Benchmark Run Time 619.24 HH
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