Layer 5 Burst Accommodating Bipolar Cell (1)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 5
Keywords: burst accommodating,Layer 5,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000137
bAC217_L5_BP_4bf5a32d90_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000137
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.03 mV
Rheobase Current Interval (0.02266, 0.02335] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0170 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop 0.7380 mV
AP 1 Steady State Amplitude Change 0.9481 mV
AP 1 Amplitude 77.2462 mV
AP 1 Width at Half Height 0.4900 ms
AP 1 Width (Peak To Trough) 2.8100 ms
AP 1 Rate of Change Peak to Trough -33.3208 mV/ms
AP 1 AHP Depth 16.3851 mV
AP2 Amplitude 76.5082 mV
AP2 Width at Half Height 0.4900 ms
AP 2 Width (Peak to Trough) 2.8400 ms
AP 2 Rate of Change Peak to Trough -32.8109 mV/ms
AP 2 AHP Depth 16.6747 mV
AP 1-2 Amplitude Change Percent -0.9554 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -1.5302 %
AP 1-2 AHP Depth Percent Change 1.7674 %
Input Resistance 601.2831 MΩ
AP 1 Delay Mean 31.5900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 97.8800 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 75.5650 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0849 %/ms
Accommodation at Steady State Mean -77.0044 %
Accommodation Rate Mean at Steady State 225.4062 ms
ISI CV 3.1823
ISI Median 225.1600 ms
ISI Burst Mean Change 27.9831 %
Spike Rate (Strong Stimulation) 10.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.4400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 41.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 32.9650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2080.1900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 68.9456 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1850.73 µm2
Number of Stems 5.0
Number of Bifurcations 30.0
Number of Branches 64.0
Overall Width 273.198 µm
Overall Height 412.814 µm
Overall Depth 317.97 µm
Average Diameter 0.633331 µm
Total Length 3446.56 µm
Total Surface 6015.9 µm2
Total Volume 1284.27 µm3
Max Euclidean Distance 325.99 µm
Max Path Distance 371.94 µm
Max Branch Order 6.0
Average Contraction 0.97103
Total Fragmentation 1022.0
Partition Asymmetry 0.369444
Average Rall's Ratio 1.11375
Average Bifurcation Angle Local 32.7221 °
Average Bifurcation Angle Remote 48.7301 °
Fractal Dimension 1.00573
Complexity Summary
State Equations 1791
Optimal Time-Step 0.00768 ms
Relative Complexity 455.74 HH
Model Size
Sections 65
Compartments 177
State Equations 1791
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00768 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 455.74 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.89 %
Max. Stable Time-Step Benchmark Run Time 874.29 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13640 Hz
CVODE Steps Per AP 681
CVODE Benchmark Run Time 470.48 HH
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