Layer 4 Burst Accommodating Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 4
Keywords: burst accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000136
bAC217_L4_MC_8a4a02932c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000136
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.95 mV
Rheobase Current Interval (0.05951, 0.06065] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0222 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.9829 mV
AP 1 Steady State Amplitude Change 1.8574 mV
AP 1 Amplitude 77.4553 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 3.2200 ms
AP 1 Rate of Change Peak to Trough -30.1152 mV/ms
AP 1 AHP Depth 19.5156 mV
AP2 Amplitude 76.4725 mV
AP2 Width at Half Height 0.4700 ms
AP 2 Width (Peak to Trough) 3.3400 ms
AP 2 Rate of Change Peak to Trough -28.6648 mV/ms
AP 2 AHP Depth 19.2679 mV
AP 1-2 Amplitude Change Percent -1.2689 %
AP 1-2 Half Width Change Percent 2.1739 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.8162 %
AP 1-2 AHP Depth Percent Change -1.2691 %
Input Resistance 347.1346 MΩ
AP 1 Delay Mean 16.4800 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 62.0300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 51.6050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1014 %/ms
Accommodation at Steady State Mean -84.0752 %
Accommodation Rate Mean at Steady State 155.0890 ms
ISI CV 3.0359
ISI Median 194.4400 ms
ISI Burst Mean Change 26.5862 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.5700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 29.7200 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.4850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2054.0400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 55.6580 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6291.11 µm2
Number of Stems 4.0
Number of Bifurcations 40.0
Number of Branches 83.0
Overall Width 258.858 µm
Overall Height 445.434 µm
Overall Depth 205.14 µm
Average Diameter 0.68263 µm
Total Length 3964.41 µm
Total Surface 8118.13 µm2
Total Volume 3035.29 µm3
Max Euclidean Distance 403.398 µm
Max Path Distance 450.419 µm
Max Branch Order 9.0
Average Contraction 0.969259
Total Fragmentation 1582.0
Partition Asymmetry 0.599232
Average Rall's Ratio 1.11412
Average Bifurcation Angle Local 56.9128 °
Average Bifurcation Angle Remote 71.4764 °
Fractal Dimension 1.00536
Complexity Summary
State Equations 2081
Optimal Time-Step 0.00787 ms
Relative Complexity 521.56 HH
Model Size
Sections 84
Compartments 206
State Equations 2081
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00787 ms
Optimal Time-Step Error 0.20 %
Optimal Time-Step Benchmark Run Time 521.56 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.41 %
Max. Stable Time-Step Benchmark Run Time 1025.36 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12714 Hz
CVODE Steps Per AP 772
CVODE Benchmark Run Time 551.30 HH
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