Layer 4 Burst Accommodating Martinotti Cell (2)

Model Type:
Cell
Neurolex IDs: Martinotti Cell
Neocortex Layer 4
Keywords: burst accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000133
bAC217_L4_MC_2eb83e1eed_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000133
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.01 mV
Rheobase Current Interval (0.05905, 0.06042] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0367 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.0888 mV
AP 1 Steady State Amplitude Change 1.9076 mV
AP 1 Amplitude 75.7528 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 2.6700 ms
AP 1 Rate of Change Peak to Trough -35.4048 mV/ms
AP 1 AHP Depth 18.7779 mV
AP2 Amplitude 74.6640 mV
AP2 Width at Half Height 0.4700 ms
AP 2 Width (Peak to Trough) 2.7200 ms
AP 2 Rate of Change Peak to Trough -34.4032 mV/ms
AP 2 AHP Depth 18.9128 mV
AP 1-2 Amplitude Change Percent -1.4373 %
AP 1-2 Half Width Change Percent 2.1739 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.8288 %
AP 1-2 AHP Depth Percent Change 0.7183 %
Input Resistance 273.5673 MΩ
AP 1 Delay Mean 23.5300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 78.3600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 60.4550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0555 %/ms
Accommodation at Steady State Mean -79.1083 %
Accommodation Rate Mean at Steady State 209.0359 ms
ISI CV 3.1854
ISI Median 190.1800 ms
ISI Burst Mean Change 20.5180 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.3000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 34.1400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.1700 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2062.3200 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5761.76 µm2
Number of Stems 3.0
Number of Bifurcations 37.0
Number of Branches 76.0
Overall Width 553.06 µm
Overall Height 552.171 µm
Overall Depth 186.9 µm
Average Diameter 0.836871 µm
Total Length 4884.68 µm
Total Surface 11637.5 µm2
Total Volume 4054.69 µm3
Max Euclidean Distance 478.001 µm
Max Path Distance 725.484 µm
Max Branch Order 11.0
Average Contraction 0.956171
Total Fragmentation 1882.0
Partition Asymmetry 0.546309
Average Rall's Ratio 1.209
Average Bifurcation Angle Local 44.9701 °
Average Bifurcation Angle Remote 69.8625 °
Fractal Dimension 1.00747
Complexity Summary
State Equations 2591
Optimal Time-Step 0.00762 ms
Relative Complexity 630.11 HH
Model Size
Sections 77
Compartments 257
State Equations 2591
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00762 ms
Optimal Time-Step Error 0.13 %
Optimal Time-Step Benchmark Run Time 630.11 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.00 %
Max. Stable Time-Step Benchmark Run Time 1200.08 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12595 Hz
CVODE Steps Per AP 627
CVODE Benchmark Run Time 595.55 HH
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