Layer 4 Burst Accommodating Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Double Bouquet Cell
Neocortex Layer 4
Keywords: burst accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000131
bAC217_L4_DBC_ba1da59a9a_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000131
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.09 mV
Rheobase Current Interval (0.09727, 0.09842] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0276 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 3.5167 mV
AP 1 Steady State Amplitude Change 3.9367 mV
AP 1 Amplitude 80.7330 mV
AP 1 Width at Half Height 0.4400 ms
AP 1 Width (Peak To Trough) 2.2700 ms
AP 1 Rate of Change Peak to Trough -46.3028 mV/ms
AP 1 AHP Depth 24.3744 mV
AP2 Amplitude 77.2163 mV
AP2 Width at Half Height 0.4300 ms
AP 2 Width (Peak to Trough) 2.2700 ms
AP 2 Rate of Change Peak to Trough -45.0061 mV/ms
AP 2 AHP Depth 24.9475 mV
AP 1-2 Amplitude Change Percent -4.3560 %
AP 1-2 Half Width Change Percent -2.2727 %
AP 1-2 Rate of Change Peak to Trough Percent Change -2.8006 %
AP 1-2 AHP Depth Percent Change 2.3513 %
Input Resistance 275.1735 MΩ
AP 1 Delay Mean 10.2200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 51.6100 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 48.2350 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1147 %/ms
Accommodation at Steady State Mean -83.5250 %
Accommodation Rate Mean at Steady State 151.0641 ms
ISI CV 3.1885
ISI Median 177.4750 ms
ISI Burst Mean Change 33.0756 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.9300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 24.2500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 22.4400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2037.5600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 38.2737 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 11222.3 µm2
Number of Stems 4.0
Number of Bifurcations 30.0
Number of Branches 63.0
Overall Width 232.49 µm
Overall Height 740.189 µm
Overall Depth 85.7 µm
Average Diameter 0.914275 µm
Total Length 3417.13 µm
Total Surface 10172.4 µm2
Total Volume 6769.53 µm3
Max Euclidean Distance 579.057 µm
Max Path Distance 643.454 µm
Max Branch Order 6.0
Average Contraction 0.915245
Total Fragmentation 3461.0
Partition Asymmetry 0.406111
Average Rall's Ratio 0.4202
Average Bifurcation Angle Local 58.5767 °
Average Bifurcation Angle Remote 65.5141 °
Fractal Dimension 1.01823
Complexity Summary
State Equations 1781
Optimal Time-Step 0.00776 ms
Relative Complexity 433.14 HH
Model Size
Sections 64
Compartments 176
State Equations 1781
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00776 ms
Optimal Time-Step Error 0.16 %
Optimal Time-Step Benchmark Run Time 433.14 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.42 %
Max. Stable Time-Step Benchmark Run Time 839.63 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12497 Hz
CVODE Steps Per AP 555
CVODE Benchmark Run Time 398.68 HH
Website & Images Copyright NeuroML © 2020 For questions: Contact us Links: Search Test |  ModelDB WS