Layer 4 Burst Accommodating Bipolar Cell (1)

Model Type:
Cell
Neurolex IDs: Bipolar Cell
Neocortex Layer 4
Keywords: burst accommodating,Layer 4,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000117
bAC217_L4_BP_712c8549fc_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000117
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -72.35 mV
Rheobase Current Interval (0.02266, 0.02289] nA
Threshold Current Interval (0.00000, 0.05859] nA
Bias Current (to -80.00 mV) -0.0076 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 3.3701 mV
AP 1 Steady State Amplitude Change 3.7109 mV
AP 1 Amplitude 92.2230 mV
AP 1 Width at Half Height 0.3800 ms
AP 1 Width (Peak To Trough) 1.8200 ms
AP 1 Rate of Change Peak to Trough -64.4904 mV/ms
AP 1 AHP Depth 25.1496 mV
AP2 Amplitude 88.8529 mV
AP2 Width at Half Height 0.3800 ms
AP 2 Width (Peak to Trough) 1.7800 ms
AP 2 Rate of Change Peak to Trough -64.1958 mV/ms
AP 2 AHP Depth 25.4156 mV
AP 1-2 Amplitude Change Percent -3.6543 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.4569 %
AP 1-2 AHP Depth Percent Change 1.0578 %
Input Resistance 1068.5787 MΩ
AP 1 Delay Mean 5.0100 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 46.6600 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 59.7000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -75.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1459 %/ms
Accommodation at Steady State Mean -86.3815 %
Accommodation Rate Mean at Steady State 151.3504 ms
ISI CV 2.9379
ISI Median 213.2450 ms
ISI Burst Mean Change 86.6747 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 2.0500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 23.7800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 23.0400 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2041.9400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 74.0593 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2094.2 µm2
Number of Stems 2.0
Number of Bifurcations 7.0
Number of Branches 15.0
Overall Width 66.2255 µm
Overall Height 873.756 µm
Overall Depth 35.52 µm
Average Diameter 1.07428 µm
Total Length 1238.74 µm
Total Surface 2532.77 µm2
Total Volume 889.847 µm3
Max Euclidean Distance 899.387 µm
Max Path Distance 914.075 µm
Max Branch Order 6.0
Average Contraction 0.990612
Total Fragmentation 256.0
Partition Asymmetry 0.857143
Average Rall's Ratio 1.51667
Average Bifurcation Angle Local 47.8552 °
Average Bifurcation Angle Remote 44.7727 °
Fractal Dimension 1.00187
Complexity Summary
State Equations 641
Optimal Time-Step 0.00819 ms
Relative Complexity 133.44 HH
Model Size
Sections 16
Compartments 62
State Equations 641
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00819 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 133.44 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.06 %
Max. Stable Time-Step Benchmark Run Time 273.13 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13783 Hz
CVODE Steps Per AP 566
CVODE Benchmark Run Time 139.74 HH
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