Layer 2/3 Burst Accommodating Nest Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000115
bAC217_L23_NBC_da24c6bffc_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000115
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.40 mV
Rheobase Current Interval (0.05127, 0.05219] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0215 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 1.3960 mV
AP 1 Steady State Amplitude Change 2.4944 mV
AP 1 Amplitude 75.7446 mV
AP 1 Width at Half Height 0.5000 ms
AP 1 Width (Peak To Trough) 2.7800 ms
AP 1 Rate of Change Peak to Trough -33.9517 mV/ms
AP 1 AHP Depth 18.6412 mV
AP2 Amplitude 74.3486 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.8600 ms
AP 2 Rate of Change Peak to Trough -32.5585 mV/ms
AP 2 AHP Depth 18.7687 mV
AP 1-2 Amplitude Change Percent -1.8430 %
AP 1-2 Half Width Change Percent 2.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.1035 %
AP 1-2 AHP Depth Percent Change 0.6840 %
Input Resistance 385.6401 MΩ
AP 1 Delay Mean 17.8700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 65.1500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 53.5100 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0987 %/ms
Accommodation at Steady State Mean -83.7387 %
Accommodation Rate Mean at Steady State 160.6176 ms
ISI CV 3.0491
ISI Median 199.2700 ms
ISI Burst Mean Change 26.3536 %
Spike Rate (Strong Stimulation) 11.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.0200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 30.6900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 26.0750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2053.6600 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4049.41 µm2
Number of Stems 6.0
Number of Bifurcations 18.0
Number of Branches 41.0
Overall Width 372.578 µm
Overall Height 469.218 µm
Overall Depth 213.33 µm
Average Diameter 0.640902 µm
Total Length 4127.54 µm
Total Surface 7735.68 µm2
Total Volume 2319.65 µm3
Max Euclidean Distance 342.603 µm
Max Path Distance 408.38 µm
Max Branch Order 6.0
Average Contraction 0.947716
Total Fragmentation 1416.0
Partition Asymmetry 0.48642
Average Rall's Ratio 1.27636
Average Bifurcation Angle Local 24.9989 °
Average Bifurcation Angle Remote 47.2955 °
Fractal Dimension 1.0071
Complexity Summary
State Equations 2081
Optimal Time-Step 0.00770 ms
Relative Complexity 478.02 HH
Model Size
Sections 42
Compartments 206
State Equations 2081
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00770 ms
Optimal Time-Step Error 0.21 %
Optimal Time-Step Benchmark Run Time 478.02 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.26 %
Max. Stable Time-Step Benchmark Run Time 920.24 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12735 Hz
CVODE Steps Per AP 704
CVODE Benchmark Run Time 478.65 HH
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