Layer 2/3 Burst Accommodating Nest Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000114
bAC217_L23_NBC_711b6a838e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000114
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.95 mV
Rheobase Current Interval (0.05905, 0.06042] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0222 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 3.7236 mV
AP 1 Steady State Amplitude Change 10.7716 mV
AP 1 Amplitude 68.0986 mV
AP 1 Width at Half Height 0.5900 ms
AP 1 Width (Peak To Trough) 6.7500 ms
AP 1 Rate of Change Peak to Trough -12.6303 mV/ms
AP 1 AHP Depth 17.1561 mV
AP2 Amplitude 64.3750 mV
AP2 Width at Half Height 0.6300 ms
AP 2 Width (Peak to Trough) 7.4700 ms
AP 2 Rate of Change Peak to Trough -10.8784 mV/ms
AP 2 AHP Depth 16.8863 mV
AP 1-2 Amplitude Change Percent -5.4679 %
AP 1-2 Half Width Change Percent 6.7797 %
AP 1-2 Rate of Change Peak to Trough Percent Change -13.8711 %
AP 1-2 AHP Depth Percent Change -1.5725 %
Input Resistance 347.1748 MΩ
AP 1 Delay Mean 18.3200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 66.5900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 59.1700 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1317 %/ms
Accommodation at Steady State Mean -86.6445 %
Accommodation Rate Mean at Steady State 152.3425 ms
ISI CV 2.8512
ISI Median 227.2450 ms
ISI Burst Mean Change 45.1626 %
Spike Rate (Strong Stimulation) 9.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.8800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 32.3500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.0450 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2053.7200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.2838 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6615.78 µm2
Number of Stems 11.0
Number of Bifurcations 21.0
Number of Branches 52.0
Overall Width 392.482 µm
Overall Height 280.464 µm
Overall Depth 232.72 µm
Average Diameter 0.70287 µm
Total Length 4473.89 µm
Total Surface 8715.6 µm2
Total Volume 2994.16 µm3
Max Euclidean Distance 343.657 µm
Max Path Distance 370.418 µm
Max Branch Order 5.0
Average Contraction 0.946456
Total Fragmentation 1358.0
Partition Asymmetry 0.488889
Average Rall's Ratio 1.41462
Average Bifurcation Angle Local 26.7902 °
Average Bifurcation Angle Remote 56.6016 °
Fractal Dimension 1.00815
Complexity Summary
State Equations 2311
Optimal Time-Step 0.00758 ms
Relative Complexity 529.42 HH
Model Size
Sections 53
Compartments 229
State Equations 2311
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00758 ms
Optimal Time-Step Error 0.31 %
Optimal Time-Step Benchmark Run Time 529.42 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 2.36 %
Max. Stable Time-Step Benchmark Run Time 1002.31 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12817 Hz
CVODE Steps Per AP 793
CVODE Benchmark Run Time 546.98 HH
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