Layer 2/3 Burst Accommodating Nest Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, nest, basket, biophysical, burst accommodating nest basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000112
bAC217_L23_NBC_421c200e4e_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000112
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.50 mV
Rheobase Current Interval (0.03204, 0.03319] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0209 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 2.1206 mV
AP 1 Steady State Amplitude Change 3.7825 mV
AP 1 Amplitude 59.8449 mV
AP 1 Width at Half Height 0.8400 ms
AP 1 Width (Peak To Trough) 12.1700 ms
AP 1 Rate of Change Peak to Trough -6.1112 mV/ms
AP 1 AHP Depth 14.5280 mV
AP2 Amplitude 57.7242 mV
AP2 Width at Half Height 0.8800 ms
AP 2 Width (Peak to Trough) 13.0600 ms
AP 2 Rate of Change Peak to Trough -5.5470 mV/ms
AP 2 AHP Depth 14.7189 mV
AP 1-2 Amplitude Change Percent -3.5435 %
AP 1-2 Half Width Change Percent 4.7619 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.2324 %
AP 1-2 AHP Depth Percent Change 1.3145 %
Input Resistance 459.9571 MΩ
AP 1 Delay Mean 32.0000 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 105.5000 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 143.9500 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -78.0229 %
Accommodation Rate Mean at Steady State 218.9614 ms
ISI CV 3.0784
ISI Median 315.8700 ms
ISI Burst Mean Change 191.7007 %
Spike Rate (Strong Stimulation) 7.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 11.6800 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 45.3700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 37.1800 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2078.7200 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 44.0830 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3279.44 µm2
Number of Stems 9.0
Number of Bifurcations 27.0
Number of Branches 62.0
Overall Width 260.165 µm
Overall Height 277.408 µm
Overall Depth 193.2 µm
Average Diameter 0.659571 µm
Total Length 4237.77 µm
Total Surface 7930.07 µm2
Total Volume 2128.34 µm3
Max Euclidean Distance 261.018 µm
Max Path Distance 293.352 µm
Max Branch Order 5.0
Average Contraction 0.953898
Total Fragmentation 1649.0
Partition Asymmetry 0.409307
Average Rall's Ratio 1.364
Average Bifurcation Angle Local 54.0316 °
Average Bifurcation Angle Remote 57.2091 °
Fractal Dimension 1.00761
Complexity Summary
Relative Complexity 537.72 HH
State Equations 2191
Optimal Time-Step 0.00772 ms
Model Size
Sections 63
Compartments 217
State Equations 2191
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13877 Hz
CVODE Steps Per AP 611
CVODE Benchmark Run Time 537.72 HH
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