Layer 2/3 Burst Accommodating Martinotti Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000111
bAC217_L23_MC_464f0bd828_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000111
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.75 mV
Rheobase Current Interval (0.07004, 0.07141] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0307 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -0.9777 mV
AP 1 Steady State Amplitude Change 1.4495 mV
AP 1 Amplitude 68.0685 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 2.3200 ms
AP 1 Rate of Change Peak to Trough -39.7390 mV/ms
AP 1 AHP Depth 24.1259 mV
AP2 Amplitude 69.0462 mV
AP2 Width at Half Height 0.4500 ms
AP 2 Width (Peak to Trough) 2.3200 ms
AP 2 Rate of Change Peak to Trough -40.3662 mV/ms
AP 2 AHP Depth 24.6033 mV
AP 1-2 Amplitude Change Percent 1.4364 %
AP 1-2 Half Width Change Percent -2.1739 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.5783 %
AP 1-2 AHP Depth Percent Change 1.9788 %
Input Resistance 293.8607 MΩ
AP 1 Delay Mean 21.6700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 70.0400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 51.3900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0612 %/ms
Accommodation at Steady State Mean -80.3948 %
Accommodation Rate Mean at Steady State 176.6542 ms
ISI CV 3.2516
ISI Median 171.9600 ms
ISI Burst Mean Change 12.4871 %
Spike Rate (Strong Stimulation) 12.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.1500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.8900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.0100 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2062.8000 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 6825.16 µm2
Number of Stems 4.0
Number of Bifurcations 42.0
Number of Branches 87.0
Overall Width 359.629 µm
Overall Height 213.925 µm
Overall Depth 316.63 µm
Average Diameter 0.735528 µm
Total Length 4939.04 µm
Total Surface 10549.4 µm2
Total Volume 3964.41 µm3
Max Euclidean Distance 311.47 µm
Max Path Distance 404.076 µm
Max Branch Order 8.0
Average Contraction 0.954332
Total Fragmentation 3153.0
Partition Asymmetry 0.403461
Average Rall's Ratio 1.26524
Average Bifurcation Angle Local 32.7906 °
Average Bifurcation Angle Remote 62.9192 °
Fractal Dimension 1.01013
Complexity Summary
State Equations 2471
Optimal Time-Step 0.00539 ms
Relative Complexity 873.88 HH
Model Size
Sections 87
Compartments 245
State Equations 2471
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00539 ms
Optimal Time-Step Error 0.19 %
Optimal Time-Step Benchmark Run Time 873.88 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.82 %
Max. Stable Time-Step Benchmark Run Time 2353.84 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 25685 Hz
CVODE Steps Per AP 136
CVODE Benchmark Run Time 837.48 HH
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