Layer 2/3 Burst Accommodating Martinotti Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti, biophysical, burst accommodating martinotti cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000110
bAC217_L23_MC_44b474bb8f_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000110
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -70.50 mV
Rheobase Current Interval (0.03204, 0.03319] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0198 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 0.5444 mV
AP 1 Steady State Amplitude Change 0.8736 mV
AP 1 Amplitude 69.9429 mV
AP 1 Width at Half Height 0.6300 ms
AP 1 Width (Peak To Trough) 8.6500 ms
AP 1 Rate of Change Peak to Trough -10.1151 mV/ms
AP 1 AHP Depth 17.5527 mV
AP2 Amplitude 69.3985 mV
AP2 Width at Half Height 0.6400 ms
AP 2 Width (Peak to Trough) 9.2700 ms
AP 2 Rate of Change Peak to Trough -9.3962 mV/ms
AP 2 AHP Depth 17.7046 mV
AP 1-2 Amplitude Change Percent -0.7783 %
AP 1-2 Half Width Change Percent 1.5873 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.1068 %
AP 1-2 AHP Depth Percent Change 0.8653 %
Input Resistance 482.6310 MΩ
AP 1 Delay Mean 30.8200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 100.1500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 117.9250 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0597 %/ms
Accommodation at Steady State Mean -77.9485 %
Accommodation Rate Mean at Steady State 208.7207 ms
ISI CV 3.1872
ISI Median 282.3700 ms
ISI Burst Mean Change 140.1846 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 10.8900 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 43.4600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 35.2750 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2082.1700 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 60.9909 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2903.43 µm2
Number of Stems 6.0
Number of Bifurcations 43.0
Number of Branches 91.0
Overall Width 257.526 µm
Overall Height 336.343 µm
Overall Depth 143.67 µm
Average Diameter 0.722352 µm
Total Length 3745.57 µm
Total Surface 7521.79 µm2
Total Volume 2125.93 µm3
Max Euclidean Distance 294.798 µm
Max Path Distance 301.466 µm
Max Branch Order 7.0
Average Contraction 0.981605
Total Fragmentation 1299.0
Partition Asymmetry 0.506138
Average Rall's Ratio 1.13679
Average Bifurcation Angle Local 30.8114 °
Average Bifurcation Angle Remote 46.2445 °
Fractal Dimension 1.00294
Complexity Summary
Relative Complexity 490.59 HH
State Equations 1961
Optimal Time-Step 0.00087 ms
Model Size
Sections 92
Compartments 194
State Equations 1961
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13246 Hz
CVODE Steps Per AP 692
CVODE Benchmark Run Time 490.59 HH
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