Layer 2/3 Burst Accommodating Martinotti Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000109
bAC217_L23_MC_40be3bf0e8_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000109
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.27 mV
Rheobase Current Interval (0.04692, 0.04807] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0221 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 1.2699 mV
AP 1 Steady State Amplitude Change 2.3904 mV
AP 1 Amplitude 72.1822 mV
AP 1 Width at Half Height 0.5300 ms
AP 1 Width (Peak To Trough) 5.0300 ms
AP 1 Rate of Change Peak to Trough -17.8183 mV/ms
AP 1 AHP Depth 17.4438 mV
AP2 Amplitude 70.9124 mV
AP2 Width at Half Height 0.5500 ms
AP 2 Width (Peak to Trough) 6.2200 ms
AP 2 Rate of Change Peak to Trough -14.2207 mV/ms
AP 2 AHP Depth 17.5402 mV
AP 1-2 Amplitude Change Percent -1.7593 %
AP 1-2 Half Width Change Percent 3.7736 %
AP 1-2 Rate of Change Peak to Trough Percent Change -20.1906 %
AP 1-2 AHP Depth Percent Change 0.5526 %
Input Resistance 386.1875 MΩ
AP 1 Delay Mean 20.6200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 72.1300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 60.2550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -75.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1438 %/ms
Accommodation at Steady State Mean -83.5992 %
Accommodation Rate Mean at Steady State 166.0068 ms
ISI CV 2.9511
ISI Median 216.4100 ms
ISI Burst Mean Change 33.9546 %
Spike Rate (Strong Stimulation) 10.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.3100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 33.8900 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 28.1350 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2046.3400 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 58.7316 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 5176.02 µm2
Number of Stems 8.0
Number of Bifurcations 16.0
Number of Branches 39.0
Overall Width 368.491 µm
Overall Height 683.022 µm
Overall Depth 261.29 µm
Average Diameter 0.733106 µm
Total Length 4115.08 µm
Total Surface 7914.6 µm2
Total Volume 2604.15 µm3
Max Euclidean Distance 497.963 µm
Max Path Distance 522.717 µm
Max Branch Order 4.0
Average Contraction 0.969397
Total Fragmentation 1247.0
Partition Asymmetry 0.433333
Average Rall's Ratio 1.1905
Average Bifurcation Angle Local 45.5872 °
Average Bifurcation Angle Remote 58.7121 °
Fractal Dimension 1.00571
Complexity Summary
State Equations 2061
Optimal Time-Step 0.00782 ms
Relative Complexity 466.47 HH
Model Size
Sections 40
Compartments 204
State Equations 2061
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00782 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 466.47 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.97 %
Max. Stable Time-Step Benchmark Run Time 911.13 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13111 Hz
CVODE Steps Per AP 766
CVODE Benchmark Run Time 498.02 HH
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