Layer 2/3 Burst Accommodating Martinotti Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Martinotti Cell
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, Martinotti
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000107
bAC217_L23_MC_1490f15199_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000107
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -69.20 mV
Rheobase Current Interval (0.06866, 0.06981] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0522 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 0.5482 mV
AP 1 Steady State Amplitude Change 0.8725 mV
AP 1 Amplitude 78.4409 mV
AP 1 Width at Half Height 0.4300 ms
AP 1 Width (Peak To Trough) 2.0500 ms
AP 1 Rate of Change Peak to Trough -48.4669 mV/ms
AP 1 AHP Depth 20.9164 mV
AP2 Amplitude 77.8927 mV
AP2 Width at Half Height 0.4300 ms
AP 2 Width (Peak to Trough) 2.0400 ms
AP 2 Rate of Change Peak to Trough -48.3592 mV/ms
AP 2 AHP Depth 20.7600 mV
AP 1-2 Amplitude Change Percent -0.6988 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -0.2223 %
AP 1-2 AHP Depth Percent Change -0.7474 %
Input Resistance 209.8269 MΩ
AP 1 Delay Mean 25.1200 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 82.6400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 63.3000 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0824 %/ms
Accommodation at Steady State Mean -76.5090 %
Accommodation Rate Mean at Steady State 242.7066 ms
ISI CV 3.2436
ISI Median 186.2600 ms
ISI Burst Mean Change 20.0974 %
Spike Rate (Strong Stimulation) 12.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.2500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 31.3400 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 27.2050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2073.1300 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 44.3326 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 8548.42 µm2
Number of Stems 4.0
Number of Bifurcations 115.0
Number of Branches 233.0
Overall Width 526.179 µm
Overall Height 692.906 µm
Overall Depth 303.89 µm
Average Diameter 0.813684 µm
Total Length 8348.15 µm
Total Surface 16904.2 µm2
Total Volume 5950.3 µm3
Max Euclidean Distance 405.813 µm
Max Path Distance 568.857 µm
Max Branch Order 10.0
Average Contraction 0.985904
Total Fragmentation 1938.0
Partition Asymmetry 0.328374
Average Rall's Ratio 0.74913
Average Bifurcation Angle Local 29.6239 °
Average Bifurcation Angle Remote 39.524 °
Fractal Dimension 1.00345
Complexity Summary
State Equations 4401
Optimal Time-Step 0.00776 ms
Relative Complexity 1128.56 HH
Model Size
Sections 234
Compartments 438
State Equations 4401
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00776 ms
Optimal Time-Step Error 0.14 %
Optimal Time-Step Benchmark Run Time 1128.56 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 1.19 %
Max. Stable Time-Step Benchmark Run Time 2189.28 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13017 Hz
CVODE Steps Per AP 556
CVODE Benchmark Run Time 1069.97 HH
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