Layer 2/3 Burst Accommodating Large Basket Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, burst accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000105
bAC217_L23_LBC_aebca8458d_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000105
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.72 mV
Rheobase Current Interval (0.07278, 0.07416] nA
Threshold Current Interval (0.29297, 0.35156] nA
Bias Current (to -80.00 mV) -0.0255 nA
Testing Temperature 34.0 °C
Stability Interval [-2.5, 15.0] nA
AP 1-2 Amplitude Drop 1.6140 mV
AP 1 Steady State Amplitude Change 3.3241 mV
AP 1 Amplitude 70.8892 mV
AP 1 Width at Half Height 0.5400 ms
AP 1 Width (Peak To Trough) 5.2900 ms
AP 1 Rate of Change Peak to Trough -16.7869 mV/ms
AP 1 AHP Depth 17.9135 mV
AP2 Amplitude 69.2752 mV
AP2 Width at Half Height 0.5600 ms
AP 2 Width (Peak to Trough) 5.6900 ms
AP 2 Rate of Change Peak to Trough -15.2670 mV/ms
AP 2 AHP Depth 17.5943 mV
AP 1-2 Amplitude Change Percent -2.2768 %
AP 1-2 Half Width Change Percent 3.7037 %
AP 1-2 Rate of Change Peak to Trough Percent Change -9.0538 %
AP 1-2 AHP Depth Percent Change -1.7821 %
Input Resistance 306.8126 MΩ
AP 1 Delay Mean 17.1700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 62.7300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 52.9600 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.1546 %/ms
Accommodation at Steady State Mean -85.4917 %
Accommodation Rate Mean at Steady State 146.0336 ms
ISI CV 3.0192
ISI Median 203.2700 ms
ISI Burst Mean Change 32.4846 %
Spike Rate (Strong Stimulation) 10.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 6.2200 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 30.2600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.5500 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2038.2400 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 7721.57 µm2
Number of Stems 8.0
Number of Bifurcations 31.0
Number of Branches 69.0
Overall Width 266.572 µm
Overall Height 347.096 µm
Overall Depth 217.24 µm
Average Diameter 0.833913 µm
Total Length 4760.51 µm
Total Surface 8980.31 µm2
Total Volume 3645.67 µm3
Max Euclidean Distance 272.047 µm
Max Path Distance 332.183 µm
Max Branch Order 7.0
Average Contraction 0.958463
Total Fragmentation 1173.0
Partition Asymmetry 0.407857
Average Rall's Ratio 0.8812
Average Bifurcation Angle Local 39.913 °
Average Bifurcation Angle Remote 64.1531 °
Fractal Dimension 1.00669
Complexity Summary
Relative Complexity 583.03 HH
State Equations 2411
Optimal Time-Step 0.00921 ms
Model Size
Sections 71
Compartments 239
State Equations 2411
Variable Time-Step Complexity
CVODE Steady State Step Frequency 12713 Hz
CVODE Steps Per AP 680
CVODE Benchmark Run Time 583.03 HH
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