Layer 2/3 Burst Accommodating Large Basket Cell (3)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000104
bAC217_L23_LBC_72e65525d3_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000104
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -73.66 mV
Rheobase Current Interval (0.15198, 0.15381] nA
Threshold Current Interval (0.41016, 0.46875] nA
Bias Current (to -80.00 mV) -0.0232 nA
Testing Temperature 34.0 °C
Stability Interval [-1.5625, 15.0] nA
AP 1-2 Amplitude Drop 9.1092 mV
AP 1 Steady State Amplitude Change 12.9273 mV
AP 1 Amplitude 77.6997 mV
AP 1 Width at Half Height 0.4400 ms
AP 1 Width (Peak To Trough) 2.6800 ms
AP 1 Rate of Change Peak to Trough -38.3630 mV/ms
AP 1 AHP Depth 25.1131 mV
AP2 Amplitude 68.5904 mV
AP2 Width at Half Height 0.4700 ms
AP 2 Width (Peak to Trough) 2.8900 ms
AP 2 Rate of Change Peak to Trough -32.6079 mV/ms
AP 2 AHP Depth 25.6464 mV
AP 1-2 Amplitude Change Percent -11.7237 %
AP 1-2 Half Width Change Percent 6.8182 %
AP 1-2 Rate of Change Peak to Trough Percent Change -15.0016 %
AP 1-2 AHP Depth Percent Change 2.1239 %
Input Resistance 221.2364 MΩ
AP 1 Delay Mean 7.8900 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 45.7700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 82.6450 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -25.0000 %
Steady State Accommodation Mean -50.0000 %
Accommodation Rate to Steady State -0.0973 %/ms
Accommodation at Steady State Mean -78.0562 %
Accommodation Rate Mean at Steady State 112.8617 ms
ISI CV 4.1078
ISI Median 168.2850 ms
ISI Burst Mean Change 236.3516 %
Spike Rate (Strong Stimulation) 12.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 3.2100 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 21.8800 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 19.9900 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2129.5800 ms
Frequency Filter Type Constant
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 16488.3 µm2
Number of Stems 6.0
Number of Bifurcations 21.0
Number of Branches 47.0
Overall Width 279.681 µm
Overall Height 494.866 µm
Overall Depth 235.36 µm
Average Diameter 0.855006 µm
Total Length 4038.46 µm
Total Surface 9526.42 µm2
Total Volume 7242.37 µm3
Max Euclidean Distance 325.426 µm
Max Path Distance 368.864 µm
Max Branch Order 5.0
Average Contraction 0.941846
Total Fragmentation 2429.0
Partition Asymmetry 0.377551
Average Rall's Ratio 1.38765
Average Bifurcation Angle Local 14.8584 °
Average Bifurcation Angle Remote 63.453 °
Fractal Dimension 1.01167
Complexity Summary
State Equations 2041
Optimal Time-Step 0.00536 ms
Relative Complexity 698.48 HH
Model Size
Sections 48
Compartments 202
State Equations 2041
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00536 ms
Optimal Time-Step Error 0.12 %
Optimal Time-Step Benchmark Run Time 698.48 HH
 
Maximum Stable Time-Step 0.03125 ms
Maximum Stable Time-Step Error 0.59 %
Max. Stable Time-Step Benchmark Run Time 1872.01 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 29516 Hz
CVODE Steps Per AP 339
CVODE Benchmark Run Time 810.29 HH
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