Layer 2/3 Burst Accommodating Large Basket Cell (2)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000103
bAC217_L23_LBC_4738b5c12c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000103
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.52 mV
Rheobase Current Interval (0.04463, 0.04578] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0214 nA
Testing Temperature 34.0 °C
Stability Interval [-1.875, 15.0] nA
AP 1-2 Amplitude Drop 1.3922 mV
AP 1 Steady State Amplitude Change 1.9697 mV
AP 1 Amplitude 74.7601 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 3.7900 ms
AP 1 Rate of Change Peak to Trough -25.2627 mV/ms
AP 1 AHP Depth 20.9856 mV
AP2 Amplitude 73.3679 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 4.0400 ms
AP 2 Rate of Change Peak to Trough -23.4789 mV/ms
AP 2 AHP Depth 21.4869 mV
AP 1-2 Amplitude Change Percent -1.8622 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.0611 %
AP 1-2 AHP Depth Percent Change 2.3886 %
Input Resistance 399.1738 MΩ
AP 1 Delay Mean 22.6300 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 78.6500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 70.8300 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -66.6667 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -82.8680 %
Accommodation Rate Mean at Steady State 169.1616 ms
ISI CV 2.8839
ISI Median 233.1100 ms
ISI Burst Mean Change 52.8740 %
Spike Rate (Strong Stimulation) 9.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.7000 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 35.7600 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 29.7950 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2073.8600 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 54.3333 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4363.56 µm2
Number of Stems 8.0
Number of Bifurcations 12.0
Number of Branches 31.0
Overall Width 435.734 µm
Overall Height 463.245 µm
Overall Depth 269.18 µm
Average Diameter 0.771286 µm
Total Length 3761.52 µm
Total Surface 7501.78 µm2
Total Volume 2441.14 µm3
Max Euclidean Distance 367.055 µm
Max Path Distance 451.189 µm
Max Branch Order 3.0
Average Contraction 0.954774
Total Fragmentation 943.0
Partition Asymmetry 0.433333
Average Rall's Ratio 0.854286
Average Bifurcation Angle Local 27.2087 °
Average Bifurcation Angle Remote 48.5526 °
Fractal Dimension 1.00849
Complexity Summary
State Equations 1881
Optimal Time-Step 0.00770 ms
Relative Complexity 433.51 HH
Model Size
Sections 32
Compartments 186
State Equations 1881
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00770 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 433.51 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.90 %
Max. Stable Time-Step Benchmark Run Time 834.79 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13201 Hz
CVODE Steps Per AP 674
CVODE Benchmark Run Time 437.97 HH
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