Layer 2/3 Burst Accommodating Large Basket Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex basket cell
Neocortex Layer 2
Neocortex Layer 3
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,Fast-spiking, interneuron, GABAergic, inhibitory, neocortex, rat, somatosensory cortex, large, basket, biophysical, burst accommodating large basket cell, Realistic Network, Neuron or other electrically excitable cell, Synapse, Spatio-temporal Activity Patterns, Detailed Neuronal Models
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000102
bAC217_L23_LBC_361cffb4c6_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000102
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Accommodating Wide AP Multi-Spikers (awMS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.28 mV
Rheobase Current Interval (0.04005, 0.04120] nA
Threshold Current Interval (0.23438, 0.29297] nA
Bias Current (to -80.00 mV) -0.0179 nA
Testing Temperature 34.0 °C
Stability Interval [-2.1875, 15.0] nA
AP 1-2 Amplitude Drop 7.2420 mV
AP 1 Steady State Amplitude Change N/A mV
AP 1 Amplitude 57.0679 mV
AP 1 Width at Half Height 0.9200 ms
AP 1 Width (Peak To Trough) 8.6200 ms
AP 1 Rate of Change Peak to Trough -8.5016 mV/ms
AP 1 AHP Depth 16.2157 mV
AP2 Amplitude 49.8259 mV
AP2 Width at Half Height 1.1900 ms
AP 2 Width (Peak to Trough) 10.8200 ms
AP 2 Rate of Change Peak to Trough -6.0420 mV/ms
AP 2 AHP Depth 15.5488 mV
AP 1-2 Amplitude Change Percent -12.6902 %
AP 1-2 Half Width Change Percent 29.3478 %
AP 1-2 Rate of Change Peak to Trough Percent Change -28.9305 %
AP 1-2 AHP Depth Percent Change -4.1126 %
Input Resistance 467.0183 MΩ
AP 1 Delay Mean 22.3400 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 80.5400 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 191.6400 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -100.0000 %
Accommodation Rate to Steady State N/A %/ms
Accommodation at Steady State Mean -82.4043 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 2.0961
ISI Median 299.7100 ms
ISI Burst Mean Change 458.5567 %
Spike Rate (Strong Stimulation) 4.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 8.5300 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 37.2000 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 31.5850 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2056.9900 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 59.7811 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 3771.18 µm2
Number of Stems 7.0
Number of Bifurcations 25.0
Number of Branches 56.0
Overall Width 208.774 µm
Overall Height 383.154 µm
Overall Depth 151.09 µm
Average Diameter 0.78215 µm
Total Length 3196.11 µm
Total Surface 6986.03 µm2
Total Volume 2376.86 µm3
Max Euclidean Distance 269.859 µm
Max Path Distance 310.371 µm
Max Branch Order 6.0
Average Contraction 0.959819
Total Fragmentation 1163.0
Partition Asymmetry 0.441905
Average Rall's Ratio 1.23079
Average Bifurcation Angle Local 42.8207 °
Average Bifurcation Angle Remote 56.4706 °
Fractal Dimension 1.00564
Complexity Summary
Relative Complexity 448.53 HH
State Equations 1651
Optimal Time-Step 0.00758 ms
Model Size
Sections 57
Compartments 163
State Equations 1651
Variable Time-Step Complexity
CVODE Steady State Step Frequency 13255 Hz
CVODE Steps Per AP 870
CVODE Benchmark Run Time 448.53 HH
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