Layer 2/3 Burst Accommodating Double Bouquet Cell (5)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000101
bAC217_L23_DBC_e5ab405051_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000101
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.46 mV
Rheobase Current Interval (0.01991, 0.02060] nA
Threshold Current Interval (0.11719, 0.17578] nA
Bias Current (to -80.00 mV) -0.0112 nA
Testing Temperature 34.0 °C
Stability Interval [-0.9375, 15.0] nA
AP 1-2 Amplitude Drop 0.5979 mV
AP 1 Steady State Amplitude Change 0.8547 mV
AP 1 Amplitude 74.0417 mV
AP 1 Width at Half Height 0.5500 ms
AP 1 Width (Peak To Trough) 6.4100 ms
AP 1 Rate of Change Peak to Trough -14.5968 mV/ms
AP 1 AHP Depth 19.5240 mV
AP2 Amplitude 73.4438 mV
AP2 Width at Half Height 0.5500 ms
AP 2 Width (Peak to Trough) 6.8900 ms
AP 2 Rate of Change Peak to Trough -13.5354 mV/ms
AP 2 AHP Depth 19.8150 mV
AP 1-2 Amplitude Change Percent -0.8075 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -7.2719 %
AP 1-2 AHP Depth Percent Change 1.4900 %
Input Resistance 760.4304 MΩ
AP 1 Delay Mean 27.8700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 92.6900 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 103.0900 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -66.6667 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.0641 %/ms
Accommodation at Steady State Mean -79.9673 %
Accommodation Rate Mean at Steady State 203.8169 ms
ISI CV 3.0068
ISI Median 273.1450 ms
ISI Burst Mean Change 118.0808 %
Spike Rate (Strong Stimulation) 8.0000 Hz
AP 1 Delay Mean (Strong Stimulation) 9.9700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 41.6500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 34.0050 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2084.0500 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 70.1185 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 1585.85 µm2
Number of Stems 4.0
Number of Bifurcations 23.0
Number of Branches 49.0
Overall Width 196.804 µm
Overall Height 433.168 µm
Overall Depth 95.62 µm
Average Diameter 0.665245 µm
Total Length 2172.41 µm
Total Surface 4249.12 µm2
Total Volume 1158.86 µm3
Max Euclidean Distance 242.586 µm
Max Path Distance 267.573 µm
Max Branch Order 7.0
Average Contraction 0.967517
Total Fragmentation 1031.0
Partition Asymmetry 0.57891
Average Rall's Ratio 1.03286
Average Bifurcation Angle Local 35.6283 °
Average Bifurcation Angle Remote 48.4291 °
Fractal Dimension 1.00514
Complexity Summary
State Equations 1081
Optimal Time-Step 0.00779 ms
Relative Complexity 258.12 HH
Model Size
Sections 50
Compartments 106
State Equations 1081
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00779 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 258.12 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.76 %
Max. Stable Time-Step Benchmark Run Time 502.63 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14373 Hz
CVODE Steps Per AP 704
CVODE Benchmark Run Time 283.15 HH
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