Layer 2/3 Burst Accommodating Double Bouquet Cell (4)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Double Bouquet Cell
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, double bouquet
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000100
bAC217_L23_DBC_d6bea44209_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000100
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Delayed Regular Spikers (dRS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -71.57 mV
Rheobase Current Interval (0.04761, 0.04852] nA
Threshold Current Interval (0.17578, 0.23438] nA
Bias Current (to -80.00 mV) -0.0187 nA
Testing Temperature 34.0 °C
Stability Interval [-1.25, 15.0] nA
AP 1-2 Amplitude Drop -1.9988 mV
AP 1 Steady State Amplitude Change -0.2112 mV
AP 1 Amplitude 68.7069 mV
AP 1 Width at Half Height 0.4600 ms
AP 1 Width (Peak To Trough) 3.1600 ms
AP 1 Rate of Change Peak to Trough -29.4627 mV/ms
AP 1 AHP Depth 24.3952 mV
AP2 Amplitude 70.7057 mV
AP2 Width at Half Height 0.4600 ms
AP 2 Width (Peak to Trough) 3.1400 ms
AP 2 Rate of Change Peak to Trough -30.3326 mV/ms
AP 2 AHP Depth 24.5386 mV
AP 1-2 Amplitude Change Percent 2.9092 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 2.9525 %
AP 1-2 AHP Depth Percent Change 0.5878 %
Input Resistance 473.9651 MΩ
AP 1 Delay Mean 20.8700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 68.5500 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 52.0800 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -50.0000 %
Steady State Accommodation Mean -25.0000 %
Accommodation Rate to Steady State -0.0533 %/ms
Accommodation at Steady State Mean -81.9673 %
Accommodation Rate Mean at Steady State 165.8921 ms
ISI CV 3.2235
ISI Median 188.5900 ms
ISI Burst Mean Change 18.4564 %
Spike Rate (Strong Stimulation) 11.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 5.1700 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.6700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 25.0650 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2044.2800 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 54.2955 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 4272.46 µm2
Number of Stems 8.0
Number of Bifurcations 20.0
Number of Branches 47.0
Overall Width 323.75 µm
Overall Height 415.787 µm
Overall Depth 231.42 µm
Average Diameter 0.496636 µm
Total Length 4337.97 µm
Total Surface 6716.17 µm2
Total Volume 2251.96 µm3
Max Euclidean Distance 366.842 µm
Max Path Distance 442.732 µm
Max Branch Order 5.0
Average Contraction 0.952712
Total Fragmentation 4014.0
Partition Asymmetry 0.483333
Average Rall's Ratio 0.781818
Average Bifurcation Angle Local 33.2371 °
Average Bifurcation Angle Remote 53.6731 °
Fractal Dimension 1.00946
Complexity Summary
State Equations 2201
Optimal Time-Step 0.00739 ms
Relative Complexity 508.15 HH
Model Size
Sections 48
Compartments 218
State Equations 2201
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00739 ms
Optimal Time-Step Error 0.10 %
Optimal Time-Step Benchmark Run Time 508.15 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.95 %
Max. Stable Time-Step Benchmark Run Time 938.64 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 25996 Hz
CVODE Steps Per AP 64
CVODE Benchmark Run Time 657.72 HH
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