Layer 2/3 Burst Accommodating Bipolar Cell (1)

Model Type:
Cell
Neurolex IDs: Neocortex Layer 2
Neocortex Layer 3
Bipolar Cell
Keywords: burst accommodating,Layer 2, Layer 3, Layer 2/3,GABAergic, inhibitory, neocortex, rat, somatosensory cortex, bipolar
Publication: Markram, et. al. (2015) Reconstruction and Simulation of Neocortical Microcircuitry.
Authors:
H Markram   Eilif Muller   Srikanth Ramaswamy   Michael Reimann   Marwan Abdellah   Carlos Sanchez   Anastasia Ailamaki   Lidia Alonso-Nanclares   Nicolas Antille   Selim Arsever   Guy Kahou   Thomas Berger   Ahmet Bilgili   Nenad Buncic   Athanassia Chalimourda   Giuseppe Chindemi   Jean-Denis Courcol   Fabien Delalondre   Vincent Delattre   Shaul Druckmann   Raphael Dumusc   James Dynes   Stefan Eilemann   Eyal Gal   Michael Gevaert   Jean-Pierre Ghobril   Albert Gidon   Joe Graham   Anirudh Gupta   Valentin Haenel   E Hay   Thomas Heinis   Juan Hernando   Michael Hines   Lida Kanari   Daniel Keller   John Kenyon   Georges Khazen   Yihwa Kim   James King   Zoltan Kisvarday   Pramod Kumbhar   Jean-Vincent Le Bé   Bruno Magalhães   Angel Merchán-Pérez   Julie Meystre   Benjamin Morrice   Jeffrey Muller   Alberto Muñoz-Céspedes   Shruti Muralidhar   Keerthan Muthurasa   Daniel Nachbaur   Taylor Newton   Max Nolte   Aleksandr Ovcharenko   Juan Palacios   Luis Pastor   Rodrigo Perin   Rajnish Ranjan   Imad Riachi   Juan Riquelme   Christian Rössert   Konstantinos Sfyrakis   Ying Shi   Julian Shillcock   Gilad Silberberg   Ricardo Silva   Farhan Tauheed   Martin Telefont   Maria Toledo-Rodriguez   Thomas Tränkler   Werner Van Geit   Jafet Diaz   Richard Walker   Yun Wang   Stefano Zaninetta   Javier DeFelipe   S Hill   Idan Segev   F Schürmann  
Translators: Padraig Gleeson  
Sources:
Files:
Model ID NeuroML File
NMLCL000087
bAC217_L23_BP_2004171a4c_0_0.cell.nml
( view NeuroML )
NMLCH000101
Ca.channel.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000111
NaTs2_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCN000001
CaDynamics_E2_NML2.nml
( view NeuroML )
Notes: None
Model Id: NMLCL000087
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Bursters (B)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -75.29 mV
Rheobase Current Interval (0.02426, 0.02472] nA
Threshold Current Interval (0.05859, 0.11719] nA
Bias Current (to -70.00 mV) 0.0051 nA
Testing Temperature 34.0 °C
Stability Interval [-0.3125, 15.0] nA
AP 1-2 Amplitude Drop 3.4076 mV
AP 1 Steady State Amplitude Change 3.2820 mV
AP 1 Amplitude 84.2889 mV
AP 1 Width at Half Height 0.4400 ms
AP 1 Width (Peak To Trough) 3.5500 ms
AP 1 Rate of Change Peak to Trough -30.9516 mV/ms
AP 1 AHP Depth 25.5894 mV
AP2 Amplitude 80.8812 mV
AP2 Width at Half Height 0.4400 ms
AP 2 Width (Peak to Trough) 3.6400 ms
AP 2 Rate of Change Peak to Trough -29.5670 mV/ms
AP 2 AHP Depth 26.7427 mV
AP 1-2 Amplitude Change Percent -4.0428 %
AP 1-2 Half Width Change Percent 0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change -4.4735 %
AP 1-2 AHP Depth Percent Change 4.5069 %
Input Resistance 1119.5674 MΩ
AP 1 Delay Mean 11.7700 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 57.3300 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 153.3550 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -33.3333 %
Steady State Accommodation Mean -33.3333 %
Accommodation Rate to Steady State -0.1047 %/ms
Accommodation at Steady State Mean -82.6016 %
Accommodation Rate Mean at Steady State 10.0000 ms
ISI CV 3.2820
ISI Median 261.1450 ms
ISI Burst Mean Change 473.2002 %
Spike Rate (Strong Stimulation) 8.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 4.8500 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 28.8500 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 26.7300 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2133.7100 ms
Frequency Filter Type Low-Pass
Frequency Filter Pass Below 62.3898 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 2271.45 µm2
Number of Stems 3.0
Number of Bifurcations 6.0
Number of Branches 14.0
Overall Width 59.8803 µm
Overall Height 308.162 µm
Overall Depth 44.74 µm
Average Diameter 1.24674 µm
Total Length 710.629 µm
Total Surface 1940.21 µm2
Total Volume 912.428 µm3
Max Euclidean Distance 184.469 µm
Max Path Distance 211.106 µm
Max Branch Order 3.0
Average Contraction 0.978976
Total Fragmentation 201.0
Partition Asymmetry 0.666667
Average Rall's Ratio 2.385
Average Bifurcation Angle Local 46.4316 °
Average Bifurcation Angle Remote 43.9907 °
Fractal Dimension 1.00297
Complexity Summary
State Equations 371
Optimal Time-Step 0.00769 ms
Relative Complexity 84.91 HH
Model Size
Sections 15
Compartments 35
State Equations 371
Fixed Time-Step Run Time vs. Voltage Potential Error
Run Time-vs-Error Optimal Time-Step 0.00769 ms
Optimal Time-Step Error 0.09 %
Optimal Time-Step Benchmark Run Time 84.91 HH
 
Maximum Stable Time-Step 0.0625 ms
Maximum Stable Time-Step Error 0.69 %
Max. Stable Time-Step Benchmark Run Time 163.26 HH
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14770 Hz
CVODE Steps Per AP 527
CVODE Benchmark Run Time 86.06 HH
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