Layer 5b Pyramidal cell

Model Type:
Cell
Neurolex IDs: Neocortex pyramidal cell layer 5-6,deep pyramidal cell, Neocortex pyramidal neuron layer 5-6, Layer 5-6 pyramidal cell, layer 5 pyramidal neuron, layer 5 pyramidal cell, Tufted layer 5 (TL5) pyramidal neurons
Keywords: mammalian Neocortical,neocortex pyramidal , layer 5b,perisomatic Na+ dendritic Ca2+ , Neuron or other electrically excitable cell, Parameter Fitting, Active Dendrites, Detailed Neuronal Models
Publication: Hay, et. al. (2011) Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties
Authors:
E Hay   S Hill   F Schürmann   H Markram   Idan Segev  
Translators: Padraig Gleeson   Matteo Farinella   Guy Eyal  
Sources:
Files:
Model ID NeuroML File
NMLCL000073
L5PC.cell.nml
( view NeuroML )
NMLCH000103
Ca_LVAst.channel.nml
( view NeuroML )
NMLCH000104
Ih.channel.nml
( view NeuroML )
NMLCH000105
Im.channel.nml
( view NeuroML )
NMLCH000107
K_Pst.channel.nml
( view NeuroML )
NMLCH000108
K_Tst.channel.nml
( view NeuroML )
NMLCH000109
Nap_Et2.channel.nml
( view NeuroML )
NMLCH000110
NaTa_t.channel.nml
( view NeuroML )
NMLCH000112
SK_E2.channel.nml
( view NeuroML )
NMLCH000113
SKv3_1.channel.nml
( view NeuroML )
NMLCH000114
pas.channel.nml
( view NeuroML )
NMLCH001436
Ca_HVA.channel.nml
( view NeuroML )
NMLCN001396
CaDynamics_E2_NML2__decay460__gamma5_01Emin4.nml
( view NeuroML )
NMLCN001404
CaDynamics_E2_NML2__decay122__gamma5_09Emin4.nml
( view NeuroML )
Notes: Layer 5b Pyramidal cell constrained by experimental data on perisomatic firing properties as well as dendritic activity during backpropagation of the action potential.
Model Id: NMLCL000073
Associated Channels:
Associated Synapses: None
Associated Networks: None
Current Clamp Response
Protocol:
Meta Protocol: -
Stimulus: -
Closest Electrophysiology Cluster
⇛Multi-Spikers (MS)
   ⇛Regular Multi-Spikers (rMS)
      ⇛Regular Spikers (RS)
Differentiating Features
Models with Similar Electrophysiology Properties
All Electrophysiology Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -77.25 mV
Rheobase Current Interval (0.34767, 0.35477] nA
Threshold Current Interval (1.75781, 1.81641] nA
Bias Current (to -70.00 mV) 0.1566 nA
Testing Temperature 6.3 °C
Stability Interval [-5.3125, 15.0] nA
AP 1-2 Amplitude Drop -0.3784 mV
AP 1 Steady State Amplitude Change 4.7085 mV
AP 1 Amplitude 72.0216 mV
AP 1 Width at Half Height 0.5100 ms
AP 1 Width (Peak To Trough) 2.9900 ms
AP 1 Rate of Change Peak to Trough -28.6000 mV/ms
AP 1 AHP Depth 13.4925 mV
AP2 Amplitude 72.4000 mV
AP2 Width at Half Height 0.5100 ms
AP 2 Width (Peak to Trough) 2.9800 ms
AP 2 Rate of Change Peak to Trough -28.9960 mV/ms
AP 2 AHP Depth 14.0082 mV
AP 1-2 Amplitude Change Percent 0.5254 %
AP 1-2 Half Width Change Percent -0.0000 %
AP 1-2 Rate of Change Peak to Trough Percent Change 1.3846 %
AP 1-2 AHP Depth Percent Change 3.8219 %
Input Resistance 36.8224 MΩ
AP 1 Delay Mean 23.6500 ms
AP 1 Delay SD 0.0000 ms
AP 2 Delay Mean 36.4700 ms
AP 2 Delay SD 0.0000 ms
Burst 1 ISI Mean 15.8050 ms
Burst 1 ISI SD 0.0000 ms
Initial Accommodation Mean -20.0000 %
Steady State Accommodation Mean -20.0000 %
Accommodation Rate to Steady State -0.0695 %/ms
Accommodation at Steady State Mean -96.6479 %
Accommodation Rate Mean at Steady State 76.5609 ms
ISI CV 3.1431
ISI Median 117.6450 ms
ISI Burst Mean Change 46.5679 %
Spike Rate (Strong Stimulation) 16.5000 Hz
AP 1 Delay Mean (Strong Stimulation) 7.1400 ms
AP 1 Delay SD (Strong Stimulation) 0.0000 ms
AP 2 Delay Mean (Strong Stimulation) 13.7700 ms
AP 2 Delay SD (Strong Stimulation) 0.0000 ms
Burst 1 ISI Mean (Strong Stimulation) 7.3000 ms
Burst 1 ISI SD (Strong Stimulation) 0.0000 ms
Ramp First Spike Time 2087.6300 ms
Frequency Filter Type High-Pass
Frequency Filter Pass Above 35.7714 Hz
3D Structure and Propagation of Activity
L-Measure Properties
Soma Surface 14386.0 µm2
Number of Stems 10.0
Number of Bifurcations 93.0
Number of Branches 196.0
Overall Width 286.779 µm
Overall Height 1290.68 µm
Overall Depth 140.18 µm
Average Diameter 0.766126 µm
Total Length 12805.2 µm
Total Surface 31463.6 µm2
Total Volume 13719.4 µm3
Max Euclidean Distance 1179.24 µm
Max Path Distance 1317.83 µm
Max Branch Order 15.0
Average Contraction 0.858626
Total Fragmentation 4138.0
Partition Asymmetry 0.496358
Average Rall's Ratio 1.62412
Average Bifurcation Angle Local 63.6606 °
Average Bifurcation Angle Remote 57.0134 °
Fractal Dimension 1.04274
Complexity Summary
Relative Complexity 970.39 HH
State Equations 5067
Optimal Time-Step 0.00790 ms
Model Size
Sections 196
Compartments 642
State Equations 5067
Variable Time-Step Complexity
CVODE Steady State Step Frequency 14264 Hz
CVODE Steps Per AP 388
CVODE Benchmark Run Time 970.39 HH
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