CA1 Pyramidal Cell

Model Type:
Cell
Neurolex IDs: Hippocampus CA1 pyramidal cell, neuron
Keywords: Glutamate
Publication: Migliore, et. al. (2005) Signal propagation in oblique dendrites of CA1 pyramidal cells
Authors:
Michele Migliore   Michele Ferrante   Giorgio Ascoli  
Translators: Padraig Gleeson  
Sources:
Files:
Current Clamp Response:
Instructions
Protocol:
Meta Protocol: -
Stimulus: -

Protocols

The dropdown contains the list of protocols to which the model was subjected. Select one from the drop down to see the model's response.

Stimuli

Some protocols have multiple stimuli (e.g. voltage levels held or current amplitudes injected). If so, a "Stimulus" slider will be visible when a protocol with multiple stimuli is selected. When visible, drag the slider left/right to see the model's response to a specific protocol stimulus. By default, the traces of all protocol stimuli are shown superimposed, each trace indicated by a different color.

Meta-Protocols

Some models will have additional meta-protocol parameters (e.g. different calcium concentration levels, random noise seeds). If available, use the second slider to see the effect of changing the meta-protocol parameter on the model response. When both sliders are visible, their values can be changed independently.

Trace detail

Using the mouse, hover near a point on a trace to see a popup with the point details. Top value shows the time. The bottom left value shows the name of the protocol stimulus, and the bottom right value shows the value of the plotted variable (e.g. voltage or current)

Zoom

The plots can be zoomed in/out to see plot details. On the right side of the plot, use the [+] and [-] buttons to zoom in/out on the center of the plot.

Pan

Once zoomed, the plots can be panned by dragging the mouse or swiping fingers sideways.

Reset Plot

Once a zoom/pan position is set, it will be maintained when the stimulus/meta-protocol parameter is changed. To reset the zoom/pan, click the circular arrow button below the zoom out button. Plot zoom will also be reset when the protocol is changed.

Morphology:
L-Measure Metric Value
Soma Surface 1320.59 µm2
Number of Stems 4.0
Number of Bifurcations 85.0
Number of Branches 173.0
Overall Width 218.975 µm
Overall Height 680.505 µm
Overall Depth 133.34 µm
Average Diameter 1.48467 µm
Total Length 12044.8 µm
Total Surface 55248.2 µm2
Total Volume 21324.8 µm3
Max Euclidean Distance 579.57 µm
Max Path Distance 658.921 µm
Max Branch Order 22.0
Average Contraction 0.923966
Total Fragmentation 2245.0
Partition Asymmetry 0.517161
Average Rall's Ratio 2.34192
Average Bifurcation Angle Local 60.7583 °
Average Bifurcation Angle Remote 41.9231 °
Fractal Dimension 1.01993
Cell Properties:
Membrane Properties
Is Passive No
Is Intrinsically Spiking No
Resting Voltage -65.00 mV
Rheobase Current Interval (0.7553, 0.7610] nA
Threshold Current Interval (1.4062, 1.4648] nA
Bias Current (to -80.00 mV) -1.3807 nA
Testing Temperature 35.0 °C
Complexity Properties
Sections 173
Compartments 3008
State Equations 27019
Stability Interval [-8.4375, 15.0] nA
 
Maximum Stable dt 0.03125 ms
Maximum Stable dt Error 4.24 %
Max. Stable dt Benchmark Run time 37705.92 HH
 
Run time-vs-Error Optimal dt 0.00553 ms
Optimal dt Error 1.97 %
Optimal dt Benchmark Run time 13651.82 HH
 
CVODE Steady State Step Frequency 13583 Hz
CVODE Steps Per AP 373
CVODE Benchmark Run time 8587.75 HH
Associated Channels:
Associated Synapses: None
Associated Networks: None
Notes: None
Model Id: NMLCL000001
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