NaP Persistent Sodium Channel

Model Type:
Channel
Neurolex IDs: Voltage Gated Sodium Channel, Na+, Nav
Keywords: persistent, sodium, Na+, rat, neocortex
Publication: Astman, et. al. (2006) Persistent sodium current in layer 5 neocortical neurons is primarily generated in the proximal axon.
Authors:
Nadav Astman   M Gutnick   Ilya Fleidervish  
Translators: Rajnish Ranjan  
Sources:
Files:
Model ID NeuroML File
NMLCH000127
Na_NaP_37.channel.nml
( view NeuroML )
Voltage Clamp Response:
Instructions
Protocol:
[Ca2+] level (mM): -
Stimulus: -

Protocols

The dropdown contains the list of protocols to which the model was subjected. Select one from the drop down to see the model's response.

Stimuli

Some protocols have multiple stimuli (e.g. voltage levels held or current amplitudes injected). If so, a "Stimulus" slider will be visible when a protocol with multiple stimuli is selected. When visible, drag the slider left/right to see the model's response to a specific protocol stimulus. By default, the traces of all protocol stimuli are shown superimposed, each trace indicated by a different color.

Meta-Protocols

Some models will have additional meta-protocol parameters (e.g. different calcium concentration levels, random noise seeds). If available, use the second slider to see the effect of changing the meta-protocol parameter on the model response. When both sliders are visible, their values can be changed independently.

Trace detail

Using the mouse, hover near a point on a trace to see a popup with the point details. Top value shows the time. The bottom left value shows the name of the protocol stimulus, and the bottom right value shows the value of the plotted variable (e.g. voltage or current)

Zoom

The plots can be zoomed in/out to see plot details. On the right side of the plot, use the [+] and [-] buttons to zoom in/out on the center of the plot.

Pan

Once zoomed, the plots can be panned by dragging the mouse or swiping fingers sideways.

Reset Plot

Once a zoom/pan position is set, it will be maintained when the stimulus/meta-protocol parameter is changed. To reset the zoom/pan, click the circular arrow button below the zoom out button. Plot zoom will also be reset when the protocol is changed.

Channel Properties:
Property Value
Testing Temperature 36 °C
State Equations 2
Stability Interval [-150.0, 70.0] mV
Associated Cells: None
Notes: None
Model Id: NMLCH000127
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